ArticleCurrent biology : CB2019
Economic Decisions through Circuit Inhibition.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Role of the primate ventral striatum as a neural hub bridging option valuation and action selection.Nature communications · 2026Article
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.bioRxiv : the preprint server for biology · 2025Article
- Orbitofrontal cortex computes gaze-dependent comparisons between attributes rather than integrated values.PLoS biology · 2025Article
- The representation of decision variables in orbitofrontal cortex is longitudinally stable.Cell reports · 2024Article
- Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex.Nature communications · 2024Article
- Orbitofrontal high-gamma reflects spike-dissociable value and decision mechanisms.bioRxiv : the preprint server for biology · 2024Article
- Article
- Neural responses in macaque prefrontal cortex are linked to strategic exploration.PLoS biology · 2023Article
- Action-rule-based cognitive control enables efficient execution of stimulus-response conflict tasks: a model validation of Simon task performance.Frontiers in human neuroscience · 2023Article
- Orbitofrontal cortex contributes to the comparison of values underlying economic choices.Nature communications · 2022Article
- Theta but not beta activity is modulated by freedom of choice during action selection.Scientific reports · 2022Article
- Logistic analysis of choice data: A primer.Neuron · 2022Review
- Optimal Allocation of Finite Sampling Capacity in Accumulator Models of Multialternative Decision Making.Cognitive science · 2022Article
- Neuronal origins of reduced accuracy and biases in economic choices under sequential offers.eLife · 2022Article
- Economic Choices under Simultaneous or Sequential Offers Rely on the Same Neural Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Evidence accumulation for value computation in the prefrontal cortex during decision making.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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- Article
- Representation of probabilistic outcomes during risky decision-making.Nature communications · 2020Article
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2 authors.
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Abstract
Economic choices between goods are thought to rely on the orbitofrontal cortex (OFC), but the decision mechanisms remain poorly understood. To shed light on this fundamental issue, we recorded from the OFC of monkeys choosing between two juices offered sequentially. An analysis of firing rates across time windows revealed the presence of different groups of neurons similar to those previously identified under simultaneous offers. This observation suggested that economic decisions in the two modalities are formed in the same neural circuit. We then examined several hypotheses on the decision mechanisms. OFC neurons encoded good identities and values in a juice-based representation (labeled lines). Contrary to previous assessments, our data argued against the idea that decisions rely on mutual inhibition at the level of offer values. In fact, we showed that previous arguments for mutual inhibition were confounded by differences in value ranges. Instead, decisions seemed to involve mechanisms of circuit inhibition, whereby each offer value indirectly inhibited neurons encoding the opposite choice outcome. Our results reconcile a variety of previous findings and provide a general account for the neuronal underpinnings of economic choices.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.