Evidence map›Paper›PMID 31679932›Full record

ArticleCurrent biology : CB2019

Social Context Enhances Hormonal Modulation of Pheromone Detection in Drosophila.

Sachin Sethi, Hui-Hao Lin, Andrew K Shepherd, Pelin C Volkan, Chih-Ying Su, Jing W Wang

Open access · hybridAbstract read
In one paragraph

Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 80 citations in OpenAlex.

  1. Environmental modulation of social isolation-induced sleep loss inbioRxiv : the preprint server for biology · 2026
    Article
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  6. Intrinsic Diversity in Odor-Evoked Calcium Rises acrossThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
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  15. Frontiers in behavioral neuroscience · 2025
    Review
  16. Article
  17. Review
  18. The role ofScience advances · 2024
    Article
  19. A neural pathway for social modulation of spontaneous locomotor activity (SoMo-SLA) inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. Peer-induced quiescence of maleFrontiers in behavioral neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sachin SethiNeurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Hui-Hao LinNeurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Andrew K ShepherdNeurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Pelin C VolkanDepartment of Biology, Duke University, Durham, NC 27708, USA; Department of Neurobiology, Duke University, Durham, NC 27708, USA.
Chih-Ying SuNeurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Jing W WangNeurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: jw800@ucsd.edu.
University of California, San Diego · USDuke University · US

Funding

Genetic analysis of state-dependent chemosensory processingR01DC016466 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SU, CHIH-YING · 2017 to 2025
$3.6M
Epigenetic Reprogramming of Behaviors with Sensory ExperienceR01NS109401 · NINDS · DUKE UNIVERSITY · PI JONES, CORBIN D, VOLKAN, PELIN C · 2018 to 2022
$2.0M
Initial Stages of Olfactory Information ProcessingR01DC015519 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SU, CHIH-YING · 2016 to 2020
$1.6M
NIDCD NIH HHS R01 DC015519NIDCD NIH HHS R01 DC016466NINDS NIH HHS R01 NS109401
6 · The paper itself

Abstract

Critical to evolutionary fitness, animals regulate social behaviors by integrating signals from both their external environments and internal states. Here, we find that population density modulates the courtship behavior of male Drosophila melanogaster in an age-dependent manner. In a competitive mating assay, males reared in a social environment have a marked advantage in courting females when pitted against males reared in isolation. Group housing promotes courtship in mature (7-day) but not immature (2-day) males; this behavioral plasticity requires the Or47b pheromone receptor. Using single-sensillum recordings, we find that group housing increases the response of Or47b olfactory receptor neurons (ORNs) only in mature males. The effect of group housing on olfactory response and behavior can be mimicked by chronically exposing single-housed males to an Or47b ligand. At the molecular level, group housing elevates Ca

Indexed as

Age FactorsAnimalsBehavior, AnimalCalcium-Calmodulin-Dependent Protein Kinase Type 1CopulationCourtshipDrosophila melanogasterDrosophila ProteinsFemaleHistone AcetyltransferasesMaleNerve Tissue ProteinsOlfactory Receptor NeuronsPheromonesPopulation DensityProtein IsoformsCalcium-Calmodulin-Dependent Protein Kinase Type 1Drosophila ProteinsHistone AcetyltransferasesNerve Tissue ProteinsPheromonesProtein IsoformsTranscription Factorsbehavioral flexibilityCaMKICBPFruitlessgroup housingjuvenile hormonesocial context

Identifiers

PMID31679932
PMCPMC6911769
OpenAlexW2986634687

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.