Evidence map›Paper›PMID 31679858›Full record

ArticleDevelopmental cell2019

An Ancient CFTR Ortholog Informs Molecular Evolution in ABC Transporters.

Guiying Cui, Jeong Hong, Yu-Wen Chung-Davidson, Daniel Infield, Xin Xu, Jindong Li, Luba Simhaev, Netaly Khazanov, Brandon Stauffer, Barry Imhoff and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Endocrine control of gill ionocyte function in euryhaline fishes.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Tweaking the catalytic efficiency of the CFTR ion channel.The Journal of general physiology · 2023
    Article
  10. Article
  11. Review
  12. Article
  13. A SNARE protein Syntaxin 17 captures CFTR to potentiate autophagosomal clearance under stress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  14. Review
  15. Electrophysiological Approaches for the Study of Ion Channel Function.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  16. Article
  17. Towards next generation therapies for cystic fibrosis: Folding, function and pharmacology of CFTR.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Guiying CuiDepartment of Pediatrics and Children's Healthcare of Atlanta, Center for Cystic Fibrosis and Airways Disease Research, Emory University, Atlanta, GA 30322, USA.
Jeong HongDepartment of Pediatrics and Children's Healthcare of Atlanta, Center for Cystic Fibrosis and Airways Disease Research, Emory University, Atlanta, GA 30322, USA; Department of Medicine, Gregory Fleming James Cystic Fibrosis Research Center, and Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Yu-Wen Chung-DavidsonDepartment of Fisheries and Wildlife, Michigan State University, East Lansing, MI 48823, USA.
Daniel InfieldDepartment of Pediatrics and Children's Healthcare of Atlanta, Center for Cystic Fibrosis and Airways Disease Research, Emory University, Atlanta, GA 30322, USA; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA.
Xin XuDepartment of Medicine, Gregory Fleming James Cystic Fibrosis Research Center, and Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Birmingham Veterans Administration Medical Center, Birmingham, AL 35233, USA.
Jindong LiDepartment of Medicine, Gregory Fleming James Cystic Fibrosis Research Center, and Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Birmingham Veterans Administration Medical Center, Birmingham, AL 35233, USA.
Luba SimhaevDepartment of Chemistry, Bar-Ilan University, Ramat Gan, Israel.
Netaly KhazanovDepartment of Chemistry, Bar-Ilan University, Ramat Gan, Israel.
Brandon StaufferDepartment of Pediatrics and Children's Healthcare of Atlanta, Center for Cystic Fibrosis and Airways Disease Research, Emory University, Atlanta, GA 30322, USA.
Barry ImhoffDepartment of Pediatrics and Children's Healthcare of Atlanta, Center for Cystic Fibrosis and Airways Disease Research, Emory University, Atlanta, GA 30322, USA.
Kirsten CottrillDepartment of Pediatrics and Children's Healthcare of Atlanta, Center for Cystic Fibrosis and Airways Disease Research, Emory University, Atlanta, GA 30322, USA.
J Edwin BlalockDepartment of Medicine, Gregory Fleming James Cystic Fibrosis Research Center, and Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Weiming LiDepartment of Fisheries and Wildlife, Michigan State University, East Lansing, MI 48823, USA.
Hanoch SenderowitzDepartment of Chemistry, Bar-Ilan University, Ramat Gan, Israel.
Eric SorscherDepartment of Pediatrics and Children's Healthcare of Atlanta, Center for Cystic Fibrosis and Airways Disease Research, Emory University, Atlanta, GA 30322, USA; Department of Medicine, Gregory Fleming James Cystic Fibrosis Research Center, and Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Nael A McCartyDepartment of Pediatrics and Children's Healthcare of Atlanta, Center for Cystic Fibrosis and Airways Disease Research, Emory University, Atlanta, GA 30322, USA.
Amit GaggarDepartment of Medicine, Gregory Fleming James Cystic Fibrosis Research Center, and Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Birmingham Veterans Administration Medical Center, Birmingham, AL 35233, USA. Electronic address: agaggar@uabmc.edu.
Children's Healthcare of Atlanta · USEmory University · USBar-Ilan University · ILBirmingham VA Medical Center · USMichigan State University · USUniversity of Alabama at Birmingham · US

Funding

A Novel Exosomal Inflammatory PathwayR35HL135710 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN · 2017 to 2023
$6.8M
A Novel Proteolytic System of Pulmonary InflammationR01HL102371 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GAGGAR, AMIT · 2010 to 2021
$3.3M
The Dynamic Nature of the CFTR Channel Pore: Coupling Gating to PermeationR01DK056481 · NIDDK · GEORGIA INSTITUTE OF TECHNOLOGY · PI MCCARTY, NAEL A · 2001 to 2013
$2.4M
BLRD VA I01 BX001756NHLBI NIH HHS R01 HL102371NHLBI NIH HHS R35 HL135710NIDDK NIH HHS R01 DK056481
6 · The paper itself

Abstract

The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel central to the development of secretory diarrhea and cystic fibrosis. The oldest CFTR ortholog identified is from dogfish shark, which retains similar structural and functional characteristics to the mammalian protein, thereby highlighting CFTR's critical role in regulating epithelial ion transport in vertebrates. However, the identification of an early CFTR ortholog with altered structure or function would provide critical insight into the evolution of epithelial anion transport. Here, we describe the earliest known CFTR, expressed in sea lamprey (Petromyzon marinus), with unique structural features, altered kinetics of activation and sensitivity to inhibition, and altered single-channel conductance compared to human CFTR. Our data provide the earliest evolutionary evidence of CFTR, offering insight regarding changes in gene and protein structure that underpin evolution from transporter to anion channel. Importantly, these data provide a unique platform to enhance our understanding of vertebrate phylogeny over a critical period of evolutionary expansion.

Indexed as

Adenosine TriphosphateAmino Acid SequenceAnimalsATP-Binding Cassette TransportersCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEvolution, MolecularHumansLampreysAdenosine TriphosphateATP-Binding Cassette TransportersCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorABC transportersCFTRchannellampreymolecular evolutionphosphorylationvertebrates

Identifiers

PMID31679858
PMCPMC7665244
OpenAlexW2982593228

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.