Evidence map›Paper›PMID 31679755›Full record

ArticleJournal of biomechanics2020

In vivo attachment site to attachment site length and strain of the ACL and its bundles during the full gait cycle measured by MRI and high-speed biplanar radiography.

Zoë A Englander, William E Garrett, Charles E Spritzer, Louis E DeFrate

Open access · greenAbstract read
In one paragraph

Article in Journal of biomechanics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Review
  4. Article
  5. An accuracy assessment of SlicerAutoscoperJournal of biomechanics · 2025
    Article
  6. Does Tibial Plateau Slope and Depth Influence ACL Strain In Vivo?Orthopaedic journal of sports medicine · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Preclinical tendon and ligament models: Beyond the 3Rs (replacement, reduction, and refinement) to 5W1H (why, who, what, where, when, how).Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
    Review
  11. Article
  12. Review
  13. Article
  14. Age- and sex-specific differences in ACL and ACL bundle size during adolescent growth.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022
    Article
  15. In search of a gold standard for objective clinical outcome: using dynamic biplane radiography to measure knee kinematics.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Zoë A EnglanderDepartment of Orthopaedic Surgery, Duke University, Durham, NC, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA.
William E GarrettDepartment of Orthopaedic Surgery, Duke University, Durham, NC, USA.
Charles E SpritzerDepartment of Radiology, Duke University, Durham, NC, USA.
Louis E DeFrateDepartment of Orthopaedic Surgery, Duke University, Durham, NC, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA; Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA. Electronic address: lou.defrate@duke.edu.
Duke University · USDuke University Hospital · US

Funding

In Vivo Knee Motion and ACL Biomechanics During Dynamic ActivitiesR01AR065527 · NIAMS · DUKE UNIVERSITY · PI DEFRATE, LOUIS E. · 2014 to 2024
$4.8M
Mechanical Biomarkers of Chronic Low Back PainR01AR075399 · NIAMS · DUKE UNIVERSITY · PI Louis E. DeFrate, Adam Goode · 2019 to 2026
$3.7M
Weight loss, in vivo cartilage mechanics, and joint healthR01AR074800 · NIAMS · DUKE UNIVERSITY · PI DEFRATE, LOUIS E. · 2019 to 2023
$1.8M
NIAMS NIH HHS R01 AR065527NIAMS NIH HHS R01 AR074800NIAMS NIH HHS R01 AR075399
6 · The paper itself

Abstract

The purpose of this study was to measure in vivo attachment site to attachment site lengths and strains of the anterior cruciate ligament (ACL) and its bundles throughout a full cycle of treadmill gait. To obtain these measurements, models of the femur, tibia, and associated ACL attachment sites were created from magnetic resonance (MR) images in 10 healthy subjects. ACL attachment sites were subdivided into anteromedial (AM) and posterolateral (PL) bundles. High-speed biplanar radiographs were obtained as subjects ambulated at 1 m/s. The bone models were registered to the radiographs, thereby reproducing the in vivo positions of the bones and ACL attachment sites throughout gait. The lengths of the ACL and both bundles were estimated as straight line distances between attachment sites for each knee position. Increased attachment to attachment ACL length and strain were observed during midstance (length = 28.5 ± 2.6 mm, strain = 5 ± 4%, mean ± standard deviation), and heel strike (length = 30.5 ± 3.0 mm, strain = 12 ± 5%) when the knee was positioned at low flexion angles. Significant inverse correlations were observed between mean attachment to attachment ACL lengths and flexion (rho = -0.87, p < 0.001), as well as both bundle lengths and flexion (rho = -0.86, p < 0.001 and rho = -0.82, p < 0.001, respectively). AM and PL bundle attachment to attachment lengths were highly correlated throughout treadmill gait (rho = 0.90, p < 0.001). These data can provide valuable information to inform design criteria for ACL grafts used in reconstructive surgery, and may be useful in the design of rehabilitation and injury prevention protocols.

Indexed as

Gait AnalysisMagnetic Resonance ImagingModels, AnatomicAdultAnterior Cruciate LigamentFemaleFemurHumansKnee JointMalePlastic Surgery ProceduresRadiographyTibiaAnterior cruciate ligamentDouble bundleFlexionKinematicsWalking

Identifiers

PMID31679755
PMCPMC7161700
OpenAlexW2981387570

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.