ArticleAsian spine journal2020
Significance of the Association between Disc Degeneration Changes on Imaging and Low Back Pain: A Review Article.
Article in Asian spine journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05978765 (Effect of Dynamic Cupping Versus Myofascial Release on Pain, Range of Motion and Functional Performance in Athletes With Non-specific Low Back Pain), which is not on this map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Dynamic Cupping Versus Myofascial Release on Pain, Range of Motion and Functional Performance in Athletes With Non-specific Low Back Pain
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Impact of Exercise on Intervertebral Disc Health: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Incidence and risk factors for modic changes in the lumbar spine: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Exercise Selection and Common Injuries in Fitness Centers: A Systematic Integrative Review and Practical Recommendations.International journal of environmental research and public health · 2022Pooled it
- A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, and Electrotherapy with and without Lumbosacral Kinesiotherapy.Medical science monitor : international medical journal of experimental and clinical research · 2024Trial
- Age-Related Transitions in Low Back Pain Pathology: A Life-Course Narrative Review.Pain and therapy · 2026Review
- Effect of exertion on the biomechanics of walking with load carriage and running in young, healthy women.Scientific reports · 2026Article
- MRI-based deep learning radiomics model for automated classification of disc degeneration in the lumbar spine.Scientific reports · 2026Article
- Chondroitinase Versus Papain Digestion Leads to Different Outcome for In Vitro Simulation of Degenerated Discs.JOR spine · 2026Article
- Cell-based therapies for intervertebral disc degeneration: Navigating the path from promise to clinical reality.Journal of orthopaedic translation · 2026Review
- Article
- O-GlcNAc transferase influences the progression of degenerative cartilage disease in lumbar facet joint osteoarthritis through FoxO1 and EGR1.Cell death discovery · 2025Article
- Patterns of shared genetic risk between chronic pain, psychopathologies, and neuroticism.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Comprehensive Analysis of Chronic Low Back Pain: Morphological and Functional Impairments, Physical Activity Patterns, and Epidemiology in a German Population-Based Cross-Sectional Study.Bioengineering (Basel, Switzerland) · 2025Article
- Human molecular mechanisms of discogenic low back pain: A scoping review.The journal of pain · 2025Article
- Degenerative relationships in lumbar intervertebral discs and facet joints: an MRI-based comparative study of asymptomatic individuals and patients with chronic and intermittent low back pain.Frontiers in bioengineering and biotechnology · 2025Article
- Effect of walking with an active ankle exoskeleton on the biomechanical responses of the lumbar spine.Frontiers in bioengineering and biotechnology · 2025Article
- Artificial intelligence and pain medicine education: Benefits and pitfalls for the medical trainee.Pain practice : the official journal of World Institute of Pain · 2025Article
- Association Between Lumbar Disc Herniation and Vertebral Endplate Modic Changes: An MRI-Based Study.Advanced biomedical research · 2025Article
- The Role of Collagen Genetic Variability in Degenerative Disc Disease and Related Conditions.Current genomics · 2025Review
- Risk factor analysis of persistent low back pain after microdiscectomy: A retrospective study.Heliyon · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Low back pain (LBP) is a major health issue resulting in a huge economic burden on the community. It not only increases the medical costs directly, but also raises the disability and loss of productivity in the general population. Symptoms include local pain over the spinal area, pain radiating to the lower leg, stiffness, and muscle tension. LBP is strongly linked with intervertebral disc degeneration that is further associated with the disruption of the complex anatomy of nucleus pulposus, annulus fibrosus, and adjacent supporting structures of the spine. Change in the shape and intensity of nucleus pulposus, decreased disc height, disc herniation, vertebral endplate changes, presence of osteophyte, and posterior high intensity zones are degenerative changes found in imaging studies. Every feature is considered while grading the severity score. Modic changes, DEBIT (disc extension beyond interspace) score, and Pfirrmann criteria are some of the scoring criteria used for evaluating disc degeneration severity. Moreover, the total number and contiguous pattern of affected discs play a crucial role in symptom generation of back pain. Many studies have reported asymptomatic patients. Thus, the correlation between degeneration severity found in imaging study and symptom severity of LBP remain unclear. This review discusses and summarizes the available literature on the significance of the association between the severity of degenerative changes found in imaging study with the presence and intensity of LBP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.