ArticleThe FEBS journal2020
Structure and activity of PPX/GppA homologs from Escherichia coli and Helicobacter pylori.
Article in The FEBS journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Sustained ppGpp production underpins months-long survival of a bacterium in growth arrest.mBio · 2026Article
- A Novel Polyphosphate-Degrading Enzyme Confers Growth on Exogenous Polyphosphate in the Archaeon Haloferax volcanii.Environmental microbiology · 2026Article
- Inorganic Polyphosphate and Human Diseases.Progress in molecular and subcellular biology · 2026Review
- Structural basis for genome-wide site-specific DNA recognition by Nuclear Factor IA.Nature communications · 2025Article
- Molecular turn inEmerging microbes & infections · 2025Article
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- Polyphosphate from Lactic Acid Bacteria: A Functional Molecule for Food and Health Applications.Foods (Basel, Switzerland) · 2025Review
- Unraveling the microecological mechanisms of phosphate-solubilizingFrontiers in microbiology · 2025Article
- Structural Evolution of Bacterial Polyphosphate Degradation Enzyme for Phosphorus Cycling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Ppx1 putative exopolyphosphatase is essential for polyphosphate accumulation inApplied and environmental microbiology · 2024Article
- Sound the (Smaller) Alarm: The Triphosphate Magic Spot Nucleotide pGpp.Infection and immunity · 2023Review
- Article
- Genomic Analysis ofGenes · 2022Article
- Article
- Model systems for studying polyphosphate biology: a focus on microorganisms.Current genetics · 2021Review
- The Phosin PptA Plays a Negative Role in the Regulation of Antibiotic Production inAntibiotics (Basel, Switzerland) · 2021Article
- Functional Insights Into the Role ofFrontiers in microbiology · 2020Article
- Structural Analysis of (p)ppGpp Reveals Its Versatile Binding Pattern for Diverse Types of Target Proteins.Frontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Rapid adaptation to environmental changes is crucial for bacterial survival. Almost all bacteria possess a conserved stringent response system to prompt transcriptional and metabolic responses toward stress. The adaptive process relies on alarmones, guanosine pentaphosphate (pppGpp), and tetraphosphate (ppGpp), to regulate global gene expression. The ppGpp is more potent than pppGpp in the regulatory activity, and pppGpp phosphohydrolase (GppA) plays a key role in (p)ppGpp homeostasis. Sharing a similar domain structure, GppA is indistinguishable from exopolyphosphatase (PPX), which mediates the metabolism of cellular inorganic polyphosphate. Here, our phylogenetic analysis of PPX/GppA homologs in bacteria shows a wide distribution with several distinct subfamilies, and our structural and functional analysis of Escherichia coli GppA and Helicobacter pylori PPX/GppA reveals unique properties of each homolog. These results explain how each homolog possesses its distinct functionality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.