ArticleBiomechanics and modeling in mechanobiology2020
Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts.
Article in Biomechanics and modeling in mechanobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Heparin and Gelatin Co-Functionalized Polyurethane Artificial Blood Vessel for Improving Anticoagulation and Biocompatibility.Bioengineering (Basel, Switzerland) · 2025Article
- Evaluation of in situ tissue-engineered arteriovenous grafts suitable for cannulation in a large animal model.Communications materials · 2025Article
- Article
- The impact of shape uncertainty on aortic-valve pressure-drop computations.International journal for numerical methods in biomedical engineering · 2021Article
- Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue.Communications biology · 2021Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Compliance mismatch between an arteriovenous dialysis graft (AVG) and the connected vein is believed to result in disturbed haemodynamics around the graft-vein anastomosis and increased mechanical loading of the vein. Both phenomena are associated with neointimal hyperplasia development, which is the main reason for AVG patency loss. In this study, we use a patient-specific fluid structure interaction AVG model to assess whether AVG haemodynamics and mechanical loading can be optimised by using novel electrospun polyurethane (ePU) grafts, since their compliance can be better tuned to match that of the native veins, compared to gold standard, expanded polytetrafluoroethylene (ePTFE) grafts. It was observed that the magnitude of flow disturbances in the vein and the size of anastomotic areas exposed to highly oscillatory shear ([Formula: see text]) and very high wall shear stress ([Formula: see text]) were largest for the ePTFE graft. Median strain and von Mises stress in the vein were similar for both graft types, whereas highest stress and strain were observed in the anastomosis of the ePU graft. Since haemodynamics were most favourable for the ePU graft simulation, AVG longevity might be improved by the use of ePU grafts.
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