Evidence map›Paper›PMID 31679066›Full record

ArticleJournal of gastroenterology2020

Short-term safety and efficacy of peroral endoscopic myotomy for the treatment of achalasia in children.

Zuqiang Liu, Yun Wang, Ying Fang, Ying Huang, Hongbin Yang, Xiaoxia Ren, Meidong Xu, Shiyao Chen, Weifeng Chen, Yunshi Zhong and 7 more

Abstract readComparative StudyMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Outcome reporting in studies of paediatric achalasia: A systematic review.Journal of pediatric gastroenterology and nutrition · 2025
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  11. Effect and safety of mark-guidedWorld journal of gastroenterology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Zuqiang LiuEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, 180 FengLin Road, Shanghai, 200032, People's Republic of China.
Yun WangEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, 180 FengLin Road, Shanghai, 200032, People's Republic of China.
Ying FangDepartment of Gastroenterology, The Children's Hospital of Xi'an City, Xi'an, China.
Ying HuangDepartment of Gastroenterology, Children's Hospital, Fudan University, Shanghai, China.
Hongbin YangDepartment of Gastroenterology, The Children's Hospital of Xi'an City, Xi'an, China.
Xiaoxia RenDepartment of Gastroenterology, The Children's Hospital of Xi'an City, Xi'an, China.
Meidong XuEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, 180 FengLin Road, Shanghai, 200032, People's Republic of China.
Shiyao ChenEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, 180 FengLin Road, Shanghai, 200032, People's Republic of China.
Weifeng ChenEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, 180 FengLin Road, Shanghai, 200032, People's Republic of China.
Yunshi ZhongEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, 180 FengLin Road, Shanghai, 200032, People's Republic of China.
Yiqun ZhangEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, 180 FengLin Road, Shanghai, 200032, People's Republic of China.
Wenzheng QinEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, 180 FengLin Road, Shanghai, 200032, People's Republic of China.
Jianwei HuEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, 180 FengLin Road, Shanghai, 200032, People's Republic of China.
Mingyan CaiEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, 180 FengLin Road, Shanghai, 200032, People's Republic of China.
Liqing YaoEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, 180 FengLin Road, Shanghai, 200032, People's Republic of China.
Quanlin LiEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, 180 FengLin Road, Shanghai, 200032, People's Republic of China. li.quanlin@zs-hospital.sh.cn.
Pinghong ZhouEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, 180 FengLin Road, Shanghai, 200032, People's Republic of China. zhou.pinghong@zs-hospital.sh.cn.
Fudan University · CNXi’an Children’s Hospital · CNChildren's Hospital of Fudan University · CN

Funding

Chen Guang Program of Shanghai Municipal Education Commission 15CG04National Natural Science Foundation of China 81670483National Natural Science Foundation of China 81873552, 81470811, 81570595Outstanding Young Doctor Training Project of Shanghai Municipal Commission of Health and Family Planning 2017YQ026Science and Technology Commission of Shanghai Municipality 18ZR1406700, 16411950400, 16DZ2280900Shanghai Rising Star Program 19QA1401190the Project of Shanghai Municipal Commission of Health and Family Planning SHDC12016203
6 · The paper itself

Abstract

backgroundPeroral endoscopic myotomy (POEM) has shown excellent results for the treatment of achalasia in adults, but studies for children are limited. The study was aimed to analyze outcomes of peroral endoscopic myotomy (POEM) in children and compared with those in adults in a large multi-center study.

methodsRecords of consecutive patients with achalasia who underwent POEM at three tertiary centers were reviewed. A total of 130 children were included in this study. The primary outcomes of perioperative outcomes and clinical follow-up data were analyzed.

resultsOne child (0.8%) experienced technical failure. Five children (3.8%) had major adverse events, including one with pneumothorax requiring drainage, two with delayed mucosa barrier failure, one with readmission, and one with vital-sign instability. Both post-POEM Eckardt score and median LES pressure were significantly lower than their pre-POEM reference values in children (0.7 vs 7.4; 7.0 vs 27.1 mmHg; both P < 0.001). During a median follow-up time of 40 months, clinical reflux rate was 27.0% and clinical failure rates at 1, 3, and 5 years were 1.8%, 3.5%, and 4.4% for children. The technical failure, major adverse events, and postoperative clinical reflux were comparable between children and adults (all P > 0.05). Kaplan-Meier analysis showed that the risk of clinical failure was lower in children than adults (log-rank test, hazard ratio = 0.37, 95% confidence interval 0.15-0.91, P = 0.023).

conclusionsPOEM can be safely performed in children with achalasia, and produce a better clinical response during long-term follow-up compared with that in adults.

Indexed as

AdolescentAdultChildChild, PreschoolEsophageal AchalasiaEsophageal Sphincter, LowerEsophagoscopyFemaleFollow-Up StudiesGastroesophageal RefluxHeller MyotomyHumansInfantLength of StayMaleNatural Orifice Endoscopic SurgeryAchalasiaChildrenOutcomePOEM

Identifiers

PMID31679066
OpenAlexW2988321621

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.