Evidence map›Paper›PMID 31679011›Full record

ArticleAmerican journal of clinical pathology2020

Cost of Unnecessary Amylase and Lipase Testing at Multiple Academic Health Systems.

Jacob P Ritter, Federico M Ghirimoldi, Laura S M Manuel, Eric E Moffett, Thomas J Novicki, James C McClay, Paula K Shireman, Bradley B Brimhall

Open access · bronzeAbstract read
In one paragraph

Article in American journal of clinical pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Jacob P RitterUniversity of Texas Health Science Center, San Antonio.
Federico M GhirimoldiUniversity of Texas Health Science Center, San Antonio.
Laura S M ManuelUniversity of Texas Health Science Center, San Antonio.
Eric E MoffettUniversity of Texas Health Science Center, San Antonio.
Thomas J NovickiMarshfield Clinic Health System, Marshfield, WI.
James C McClayUniversity of Nebraska Medical Center, Omaha.
Paula K ShiremanUniversity of Texas Health Science Center, San Antonio.
Bradley B BrimhallUniversity of Texas Health Science Center, San Antonio.
The University of Texas Health Science Center at San Antonio · USMarshfield Clinic · USSouth Texas Veterans Health Care System · USUniversity Health System · USUniversity of Nebraska Medical Center · US

Funding

Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HOLSTEIN, SARAH A · 2016 to 2025
$42.8M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR002645 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2018 to 2022
$20.4M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5M
PATHOBIOLOGY OF OCCLUSIVE VASCULAR DISEASET32HL007446 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jean Chrisostome Bopassa · 1985 to 2026
$8.9M
Harnessing the power of CTSA-CDRN data networks: Using social determinants of health, frailty and functional status to identify at-risk patients and improve risk adjustmentU01TR002393 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SHIREMAN, PAULA K · 2018 to 2021
$3.1M
NCATS NIH HHS U01 TR002393NCATS NIH HHS UL1 TR001120NCATS NIH HHS UL1 TR002645NHLBI NIH HHS T32 HL007446NIGMS NIH HHS U54 GM115458
6 · The paper itself

Abstract

objectivesTo determine adherence to Choosing Wisely recommendations for using serum lipase to diagnose acute pancreatitis rather than amylase, avoiding concurrent amylase/lipase testing and avoiding serial measurements after the first elevated test as both are ineffective for tracking disease course.

methodsDeidentified laboratory data from four large health systems were analyzed to determine concurrent testing rates, serial testing rates, and provider-ordering patterns.

resultsWhile most providers adhered to recommendations with 58,693 lipase-only tests ordered and performed, 86% of amylase tests were performed concurrently with lipase. Ambulatory, inpatient, and emergency department settings revealed concurrent rates of 51%, 41%, and 8%, respectively. Services with order sets containing both amylase and lipase were associated with higher rates of concurrent testing.

conclusionsConcurrent amylase/lipase testing is an area of opportunity to improve compliance, especially in ambulatory settings. Revision of order sets and provider education could be interventions to reduce unnecessary testing and save costs.

Indexed as

Health Care CostsAmylasesBiomarkersDiagnostic Tests, RoutineHumansLipasePancreatitisAmylasesBiomarkersLipaseAcute pancreatitisChoosing WiselyDiagnosisLaboratory utilization

Identifiers

PMID31679011
PMCPMC7315000
OpenAlexW2984045754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.