ArticleBMJ open2019
The structure and predictive value of intrinsic capacity in a longitudinal study of ageing.
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06753643 (Implementing the National Frailty Policy in Singapore's Primary Care), which is not on this map. Cited by 215 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Implementing the National Frailty Policy in Singapore's Primary Care: A Pilot Feasibility Study of The Intrinsic Capacity ProMotion in PrimAry Care for The Frail Program (IMPACTFrail)
Who cites it
215 citing papers in PubMed, 6 syntheses or guidelines pooled it, 362 citations in OpenAlex.
- Transitions and trajectories in intrinsic capacity states over time: a systematic review.BMC geriatrics · 2025Pooled it
- Sensor for sports applications: monitoring and assessment of intrinsic capacity enhancement in older adults during brisk walking.Frontiers in public health · 2025Pooled it
- Instruments for measuring the neuromuscular function domain of vitality capacity in older persons: an umbrella review.European geriatric medicine · 2024Pooled it
- Prevalence of intrinsic capacity decline among community-dwelling older adults: a systematic review and meta-analysis.Aging clinical and experimental research · 2024Pooled it
- A State-of-the-Art of Exoskeletons in Line with the WHO's Vision on Healthy Aging: From Rehabilitation of Intrinsic Capacities to Augmentation of Functional Abilities.Sensors (Basel, Switzerland) · 2024Pooled it
- A systematic review of the measurement properties of aspects of psychological capacity in older adults.Age and ageing · 2023Pooled it
- Effectiveness of a multidomain lifestyle counseling intervention on intrinsic capacity in older women: a randomized clinical trial.Aging clinical and experimental research · 2025Trial
- Impact of a nurse-led multidomain intervention on intrinsic capacity among community-dwelling older adults in China: a cluster randomized trial.BMC public health · 2025Trial
- Trial
- What day is today? Cognitive capacity and the risk of incident dementia in the context of integrated care for older people (ICOPE Step 1).Aging clinical and experimental research · 2021Trial
- Intrinsic capacity and mortality in community-dwelling octogenarians: a network analysis from the ilSIRENTE study.GeroScience · 2026Article
- Intergenerational educational mobility and intrinsic capacity in later life: a harmonised analysis of individuals from five countries.Journal of global health · 2026Article
- Possible osteosarcopenia is associated with loss in intrinsic capacity and early cognitive deficits: a longitudinal study of older adults in Singapore.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Intrinsic capacity and self-perceived health among home-dwelling older adults: The HUNT study.The Journal of frailty & aging · 2026Article
- Intrinsic capacity: Making health the core outcome of Healthspan research.The Journal of frailty & aging · 2026Article
- Association of Composite and Domain-Specific Intrinsic Capacity and Frailty Among Older Adults in India: Evidence from the Longitudinal Ageing Study in India (LASI).Journal of frailty, sarcopenia and falls · 2026Article
- Definition and conceptual framework of the psychological domain of intrinsic capacity in healthy ageing: outcomes from the MOSAIC International Working Group.The journal of nutrition, health & aging · 2026Article
- Association of Changes in Intrinsic Capacity With Cognitive Decline and Dementia: A Prospective Cohort Study.Neurology · 2026Article
- Rethinking frailty and intrinsic capacity in medical education in Europe through an EAMA student collaboration.European geriatric medicine · 2026Article
- Article
155 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
objectivesTo assess the validity of the WHO concept of intrinsic capacity in a longitudinal study of ageing; to identify whether this overall measure disaggregated into biologically plausible and clinically useful subdomains; and to assess whether total capacity predicted subsequent care dependence.
designStructural equation modelling of biomarkers and self-reported measures in the English Longitudinal Study of Ageing including exploratory factor analysis, exploratory bi-factor analysis and confirmatory factor analysis. Longitudinal mediation and moderation analysis of incident care dependence. SETTINGS: Community, United Kingdom.
participants2560 eligible participants aged over 60 years.
main outcome measuresActivities of daily living (ADL) and instrumental activities of daily living (IADL).
resultsOne general factor (intrinsic capacity) and five subfactors emerged: locomotor, cognitive; psychological; sensory; and 'vitality'. This structure is consistent with biological theory and the model had a good fit for the data (χ
conclusionsThe WHO construct of intrinsic capacity appears to provide valuable predictive information on an individual's subsequent functioning, even after accounting for the number of multimorbidities. The proposed general factor and subdomain structure may contribute to a transformative paradigm for future research and clinical practice.
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Registered trials
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