Observational studyBMJ open2019
Association between syphilis seroprevalence and age among blood donors in Southern China: an observational study from 2014 to 2017.
Observational study in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- A systematic review and meta-analysis of the prevalence and risk of syphilis among blood donors in Thailand.Scientific reports · 2025Pooled it
- Syphilis epidemic among men who have sex with men: A global systematic review and meta-analysis of prevalence, incidence, and associated factors.Journal of global health · 2024Pooled it
- High Prevalence of Occult Hepatitis B Virus Co-Infection Identified in Treponema Pallidum-Positive Blood Donations: Implications for HBV Risk Reduction.Pathogens (Basel, Switzerland) · 2026Article
- Trend in the detection rate of syphilis among older adults: time series analysis, Brazil, 2014-2023.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2026Article
- Article
- Epidemiological and Population Characteristics of Seroprevalence of TTIs Among Voluntary Blood Donors - Guangzhou City, Guangdong Province, China, 2014-2023.China CDC weekly · 2025Article
- [Seroprevalence of infectious agents in blood donors and their components].Revista medica del Instituto Mexicano del Seguro Social · 2025Observational
- Related Factors of Syphilis Positive Rate in Blood Donors During the COVID-19 Epidemic.International journal of general medicine · 2024Article
- Advancing Precise Syphilis Diagnosis: A Nontreponemal IgM Antibody-Based Model for Latent Syphilis Staging.Infection and drug resistance · 2024Article
- Serological testing for syphilis in the differential diagnosis of cognitive decline and polyneuropathy in geriatric patients.BMC geriatrics · 2023Article
- Clinical analysis and methodological evaluation of syphilis infection in patients in a first-class tertiary hospital in Suzhou, China.American journal of clinical and experimental immunology · 2023Article
- Epidemiology, Management, Quality of Testing and Cost of Syphilis in Germany: A Retrospective Model Analysis.Frontiers in public health · 2022Article
- Prevalence of Syphilis Infections Among Volunteer Blood Donors in Jinan Blood Center, China: A 15-Year Retrospective Study.Infection and drug resistance · 2022Article
- Infectious diseases among elderly persons: Results from a population-based observational study in Shandong province, China, 2013-2017.Journal of global health · 2021Observational
- Sexually transmitted infections in the elderly: A growing concern in geriatric care.Indian journal of sexually transmitted diseases and AIDSReview
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study investigated the association between syphilis seroprevalence and age among blood donors, and described the distribution of serological titres among syphilis-infected donors, aiming to confirm the syphilis epidemic characteristics and to promote effective interventions for older adults.
methodsData were obtained from the Shenzhen Programme for Syphilis Prevention and Control in 2014-2017. Blood samples were screened using the ELISAs, and confirmed using the
resultsAmong 394 792 blood donors, 733 tested TPPA and TRUST positive (active infection), and 728 tested only TPPA positive (historical infection). The overall prevalence of syphilis seropositivity was 370.1 per 100 000 (95% CI 351.1 to 389.0 per 100 000); the prevalence of active infection was 185.7 per 100 000 (95% CI 172.2 to 199.1 per 100 000). People aged ≥45 years displayed a prevalence of 621.8 per 100 000 in syphilis seropositivity and 280.5 per 100 000 in active infection, which were 3.8 times and 2.4 times higher than that for people aged <25 years, respectively. The prevalence of syphilis seropositivity (χ
conclusionsThe findings confirm the high prevalence of syphilis among older adults, and suggest the need to increase awareness among healthcare providers and deliver more targeted prevention interventions for older adults to promote early testing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.