Evidence map›Paper›PMID 31678913›Full record

ArticleiScience2019

Plant-Derived Exosomal Nanoparticles Inhibit Pathogenicity of Porphyromonas gingivalis.

Kumaran Sundaram, Daniel P Miller, Anil Kumar, Yun Teng, Mohammed Sayed, Jingyao Mu, Chao Lei, Mukesh K Sriwastva, Lifeng Zhang, Jun Yan and 8 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 121 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Fermentation-Derived 6-Shogaol fromInternational journal of molecular sciences · 2026
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  20. Nanovesicles fromPharmaceuticals (Basel, Switzerland) · 2025
    Article

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Kumaran SundaramJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 South Hancock Street, Louisville, KY 40202, USA.
Daniel P MillerDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY 40202, USA.
Anil KumarJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 South Hancock Street, Louisville, KY 40202, USA.
Yun TengJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 South Hancock Street, Louisville, KY 40202, USA.
Mohammed SayedDepartment of Computer Engineering and Computer Science, University of Louisville, Louisville, KY 40202, USA.
Jingyao MuJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 South Hancock Street, Louisville, KY 40202, USA.
Chao LeiJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 South Hancock Street, Louisville, KY 40202, USA.
Mukesh K SriwastvaJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 South Hancock Street, Louisville, KY 40202, USA.
Lifeng ZhangJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 South Hancock Street, Louisville, KY 40202, USA.
Jun YanJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 South Hancock Street, Louisville, KY 40202, USA.
Michael L MerchantKidney Disease Program and Clinical Proteomics Center, University of Louisville, Louisville, KY, USA.
Liqing HeDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA.
Yuan FangDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA.
Shuangqin ZhangDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.
Xiang ZhangDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA.
Juw W ParkDepartment of Computer Engineering and Computer Science, University of Louisville, Louisville, KY 40202, USA; KBRIN Bioinformatics Core, University of Louisville, Louisville, KY 40202, USA.
Richard J LamontDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY 40202, USA.
Huang-Ge ZhangRobley Rex Veterans Affairs Medical Center, Louisville, KY 40206, USA; James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 South Hancock Street, Louisville, KY 40202, USA. Electronic address: h0zhan17@louisville.edu.

Funding

Understanding the Host-Microbiome-Therapeutic Triad: Implications for Designing Alternative IntravaginalP20GM125504 · NIGMS · UNIVERSITY OF LOUISVILLE · PI James Tristan Collins · 2018 to 2026
$24.4M
Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2016 to 2025
$24.1M
The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI SHIRISH S BARVE · 2016 to 2026
$17.9M
MOLECULAR ASPECTS OF ORAL PLAQUE FORMATIONR01DE012505 · NIDCR · UNIVERSITY OF WASHINGTON · PI Richard J Lamont, JAN S POTEMPA · 1998 to 2026
$9.5M
Plant exosomes non-coding RNA-mediated anti-inflammatory mechanismsR01AT008617 · NCCIH · UNIVERSITY OF LOUISVILLE · PI HUANG-GE ZHANG · 2016 to 2026
$5.7M
P GINGIVALIS INTERACTIONS WITH GINGIVAL EPITHELIAL CELLSR01DE011111 · NIDCR · UNIVERSITY OF WASHINGTON · PI HARIBABU BODDULURI, Richard J Lamont · 1995 to 2026
$5.4M
P.gingivalis Interactions with Gingival Epithelial CellsR37DE011111 · NIDCR · UNIVERSITY OF LOUISVILLE · PI LAMONT, RICHARD J · 2009 to 2018
$3.6M
Fruit exosome-like particles for therapeutic delivery of extracellular miRNAsUH3TR000875 · NCATS · UNIVERSITY OF LOUISVILLE · PI ZHANG, HUANG-GE · 2015 to 2017
$2.7M
Ultra Performance Liquid Chromatography High Resolution High Mass Accuracy Mass SpectrometerS10OD020106 · OD · UNIVERSITY OF LOUISVILLE · PI ZHANG, XIANG · 2015 to 2015
$600k
Polymicrobial Synergy between Treponema denticola and Porphyromonas gingivalisK99DE028346 · NIDCR · UNIVERSITY OF LOUISVILLE · PI MILLER, DANIEL PATRICK · 2018 to 2019
$214k
NCATS NIH HHS UH3 TR000875NCCIH NIH HHS R01 AT008617NIAAA NIH HHS P50 AA024337NIDCR NIH HHS K99 DE028346NIDCR NIH HHS R01 DE011111NIDCR NIH HHS R01 DE012505NIDCR NIH HHS R37 DE011111NIGMS NIH HHS P20 GM113226NIGMS NIH HHS P20 GM125504NIH HHS S10 OD020106
6 · The paper itself

Abstract

Plant exosomes protect plants against infection; however, whether edible plant exosomes can protect mammalian hosts against infection is not known. In this study, we show that ginger exosome-like nanoparticles (GELNs) are selectively taken up by the periodontal pathogen Porphyromonas gingivalis in a GELN phosphatidic acid (PA) dependent manner via interactions with hemin-binding protein 35 (HBP35) on the surface of P. gingivalis. Compared with PA (34:2), PA (34:1) did not interact with HBP35, indicating that the degree of unsaturation of PA plays a critical role in GELN-mediated interaction with HBP35. On binding to HBP35, pathogenic mechanisms of P. gingivalis were significantly reduced following interaction with GELN cargo molecules, including PA and miRs. These cargo molecules interacted with multiple pathogenic factors in the recipient bacteria simultaneously. Using edible plant exosome-like nanoparticles as a potential therapeutic agent to prevent/treat chronic periodontitis was further demonstrated in a mouse model.

Indexed as

BacteriologyBiochemistryBiological SciencesImmunologyMicrobiologyMolecular BiologyOral Microbiology

Identifiers

PMID31678913
PMCPMC6838522

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.