ArticleEnvironmental research2019
Exposure to 17 trace metals in pregnancy and associations with urinary oxidative stress biomarkers.
Article in Environmental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 70 citations in OpenAlex.
- Associations of exposure to cotinine, polycyclic aromatic hydrocarbon, and metal(loid) mixtures during pregnancy with birth weight: the MIEHR study.Journal of exposure science & environmental epidemiology · 2026Article
- Maternal and Newborn Factors Associated with Meconium Metal Concentrations: A Cross-Sectional Study.Toxics · 2026Article
- Oxidative Stress-Related Metabolomic Alterations in Pregnancy: Evidence from Exposure to Air Pollution, Metals/Metalloid, and Tobacco Smoke.Antioxidants (Basel, Switzerland) · 2025Review
- Association between size-resolved PMScientific reports · 2025Article
- Exposure to a mixture of four metals and associations with urinary oxidative stress biomarkers in Uruguayan adolescents.Journal of environmental exposure assessment · 2025Article
- IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Evidence for reproductive health effects following exposure to hydraulic fracturing chemical mixtures.Reproduction (Cambridge, England) · 2024Review
- Article
- Prenatal per- and polyfluoroalkyl substances (PFAS) and maternal oxidative stress: Evidence from the LIFECODES study.Chemosphere · 2024Article
- Modeling variation in mixture effects over space with a Bayesian spatially varying mixture model.Statistics in medicine · 2024Article
- The Correlation between Metal Mixed Exposure and Lung Function in Different Ages of the Population.Metabolites · 2024Article
- Analyzing socio-environmental determinants of bone and soft tissue cancer in Indonesia.BMC cancer · 2024Article
- Close association of PFASs exposure with hepatic fibrosis than steatosis: evidences from NHANES 2017-2018.Annals of medicine · 2023Article
- Does the Micronutrient Molybdenum Have a Role in Gestational Complications and Placental Health?Nutrients · 2023Review
- Rapid extraction and analysis of oxidative stress and DNA damage biomarker 8-hydroxy-2'-deoxyguanosine (8-OHdG) in urine: Application to a study with pregnant women.International journal of hygiene and environmental health · 2023Article
- Modeling historic environmental pollutant exposures and non-Hodgkin lymphoma risk.Environmental research · 2023Article
- The relationship between urinary selenium levels and risk of gestational diabetes mellitus: A nested case-control study.Frontiers in public health · 2023Article
- Prenatal exposure to heavy metal mixtures and anthropometric birth outcomes: a cross-sectional study.Environmental health : a global access science source · 2022Article
- Estimating mixture effects and cumulative spatial risk over time simultaneously using a Bayesian index low-rank kriging multiple membership model.Statistics in medicine · 2022Article
- Article
- Semiparametric analysis of a generalized linear model with multiple covariates subject to detection limits.Statistics in medicine · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundExposure to some toxic metals, such as lead and cadmium, has been associated with increased oxidative stress. However less is known about other metals and metal mixtures, especially in pregnant women who are a vulnerable population.
methodsTo study the relationship between exposure to trace metals and oxidative stress, we analyzed a panel of 17 metals and two oxidative stress biomarkers (8-isoprostane and 8-hydroxydeoxyguanosine [8-OHdG]) in urine samples collected at ~26 weeks gestation from pregnant women in Boston (n = 380). We used linear regression models to calculate percent differences and 95% confidence intervals (CI) in oxidative stress markers for an interquartile range (IQR) increase in each urinary metal with adjustment for other metals. In addition, we applied principal components analysis (PCA) and Bayesian kernel machine regression (BKMR), to examine cumulative effects (within correlated groups of exposures as well as overall) and interactions.
resultsWe estimated 109% (95% CI: 47, 198) higher 8-isoprostane and 71% (95% CI: 45, 102) higher 8-OHdG with an IQR increase in urinary selenium (Se). We also estimated higher 8-isoprostane (47%, 95% CI: 20.5, 79.4) and 8-OHdG (15.3%, 95% CI: 5.09, 26.5) in association with urinary copper (Cu). In our PCA, we observed higher 8-isoprostane levels in association with the "essential" PC (highly loaded by Cu, Se, and Zinc). In BKMR analyses, we also estimated higher levels of both oxidative stress biomarkers with increasing Se and Cu as well as increasing levels of both oxidative stress biomarkers in association with cumulative concentrations of urinary trace metals.
conclusionWe observed higher 8-isoprostane and 8-OHdG levels in association with urinary trace metals and elements, particularly Se and Cu, in linear models and using mixtures approaches. Additionally, increasing cumulative exposure to urinary trace metals was associated with higher levels of both oxidative stress biomarkers. The beneficial effects of these compounds should be carefully questioned.
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