Evidence map›Paper›PMID 31678540›Full record

ArticleBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation2020

Inflammatory Cytokine Profile in Individuals with Inherited Chromosomally Integrated Human Herpesvirus 6.

Daniel P Weschke, Wendy M Leisenring, Richard L Lawler, Terry Stevens-Ayers, Meei-Li Huang, Keith R Jerome, Danielle M Zerr, John A Hansen, Michael Boeckh, Joshua A Hill

Open access · greenAbstract read
In one paragraph

Article in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Daniel P WeschkeVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Wendy M LeisenringClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Richard L LawlerClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Terry Stevens-AyersVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Meei-Li HuangDepartment of Laboratory Medicine, University of Washington, Seattle, Washington.
Keith R JeromeVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Laboratory Medicine, University of Washington, Seattle, Washington.
Danielle M ZerrDepartment of Pediatrics, University of Washington, Seattle, Washington.
John A HansenClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Medicine, University of Washington, Seattle, Washington.
Michael BoeckhVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Medicine, University of Washington, Seattle, Washington.
Joshua A HillVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Medicine, University of Washington, Seattle, Washington. Electronic address: jahill3@fredhutch.org.
University of Washington · USFred Hutch Cancer Center · USInfectious Disease Research Institute · US

Funding

VIRUS-MEDIATED MYELOSUPPRESSIONP01CA018029 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MADHAV V DHODAPKAR · 1985 to 2026
$128.4M
Project 3: Stem Cell Allografts for Lymphoid MalignanciesP01CA078902 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SANDMAIER, BRENDA MARIE · 1999 to 2025
$46.1M
Project 3: Gene Therapy for Correction of Blood DisordersP01HL122173 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KIEM, HANS-PETER · 2015 to 2019
$12.9M
Infections in Hematopoietic Cell Transplant RecipientsK24HL093294 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BOECKH, MICHAEL J · 2009 to 2019
$1.5M
Human Herpesvirus 6 in Lower Respiratory Tract Disease and Chromosomal Integration after Hematopoietic Cell TransplantationK23AI119133 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HILL, JOSHUA AIDEN · 2015 to 2019
$922k
Impact of Comorbidities on Outcomes of Allogeneic TransplantationR00HL088021 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SORROR, MOHAMED · 2011 to 2013
$735k
Impact of Comorbidities on Outcomes of Allogeneic TransplantationK99HL088021 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SORROR, MOHAMED · 2007 to 2008
$178k
NCI NIH HHS P01 CA018029NCI NIH HHS P01 CA078902NHLBI NIH HHS K24 HL093294NHLBI NIH HHS K99 HL088021NHLBI NIH HHS P01 HL122173NHLBI NIH HHS R00 HL088021NIAID NIH HHS K23 AI119133
6 · The paper itself

Abstract

Acute graft-versus-host-disease (aGVHD) is a major complication following hematopoietic cell transplantations (HCTs). We have shown that HCT recipients in whom either the donor or patient had inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) have a higher incidence of developing more severe aGVHD. Previous studies established that increased proinflammatory cytokines are associated with increased risk for aGVHD and nonrelapse mortality post-HCT. We hypothesized that HCT recipients with donor or recipient iciHHV-6 (iciHHV-6

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationHerpesvirus 6, HumanAcute DiseaseCytokinesHumansTissue DonorsCytokinesCytokinesGVHDiciHHV-6Transplant

Identifiers

PMID31678540
PMCPMC6943191
OpenAlexW2988307513

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.