Evidence map›Paper›PMID 31678512›Full record

ArticleBiochimica et biophysica acta. Molecular and cell biology of lipids2020

Pho85 and PI(4,5)P

Jose A Prieto, Francisco Estruch, Isaac Córcoles-Sáez, Maurizio Del Poeta, Robert Rieger, Irene Stenzel, Francisca Randez-Gil

Open access · greenAbstract read
In one paragraph

Article in Biochimica et biophysica acta. Molecular and cell biology of lipids, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  5. Review
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  8. TheFrontiers in microbiology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Jose A PrietoDepartment of Biotechnology, Instituto de Agroquímica y Tecnología de los Alimentos, Consejo Superior de Investigaciones Científicas, Avda. Agustín Escardino, 7, 46980 Paterna, Valencia, Spain.
Francisco EstruchDepartament of Biochemistry and Molecular Biology, Universitat de València, Dr. Moliner 50, Burjassot 46100, Spain.
Isaac Córcoles-SáezDepartment of Biotechnology, Instituto de Agroquímica y Tecnología de los Alimentos, Consejo Superior de Investigaciones Científicas, Avda. Agustín Escardino, 7, 46980 Paterna, Valencia, Spain.
Maurizio Del PoetaDepartment of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY, United States of America; Veterans Administration Medical Center, Northport, NY, United States of America.
Robert RiegerProteomics Center, Stony Brook University, Stony Brook, NY, United States of America.
Irene StenzelDepartment of Cellular Biochemistry, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Francisca Randez-GilDepartment of Biotechnology, Instituto de Agroquímica y Tecnología de los Alimentos, Consejo Superior de Investigaciones Científicas, Avda. Agustín Escardino, 7, 46980 Paterna, Valencia, Spain. Electronic address: randez@iata.csic.es.
Consejo Superior de Investigaciones Científicas · ESInstituto de Agroquímica y Tecnología de Alimentos · ESMartin Luther University Halle-Wittenberg · DENorthport VA Medical Center · USStony Brook University · USUniversitat de València · ES

Funding

New antifungals targeting the synthesis of fungal sphingolipidsR01AI116420 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI Maurizio Del Poeta · 2016 to 2026
$7.6M
Lipid-mediated fungal pathogenesisR01AI125770 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI DEL POETA, MAURIZIO · 2016 to 2025
$6.2M
NIAID NIH HHS R01 AI116420NIAID NIH HHS R01 AI125770
6 · The paper itself

Abstract

Lipid homeostasis allows cells to adjust membrane biophysical properties in response to changes in environmental conditions. In the yeast Saccharomyces cerevisiae, a downward shift in temperature from an optimal reduces membrane fluidity, which triggers a lipid remodeling of the plasma membrane. How changes in membrane fluidity are perceived, and how the abundance and composition of different lipid classes is properly balanced, remain largely unknown. Here, we show that the levels of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P

Indexed as

AcclimatizationCell MembraneCold TemperatureCyclin-Dependent KinasesGene Expression Regulation, FungalGlycogen Synthase Kinase 3Lipid MetabolismMembrane FluidityMetabolic Networks and PathwaysPhosphatidylinositol 4,5-DiphosphateSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSignal TransductionCyclin-Dependent KinasesGlycogen Synthase Kinase 3MCK1 protein, S cerevisiaeOrm2 protein, S cerevisiaePHO85 protein, S cerevisiaePhosphatidylinositol 4,5-DiphosphateSaccharomyces cerevisiae Proteins1-IP(7)Low temperatureOrm2PhosphoinositidePhospholipidSaccharomyces cerevisiaeSphingoid basesSphingolipidTORC2-Pkh1-Ypk1 signaling moduleTriacylglyceride

Identifiers

PMID31678512
PMCPMC7254492
OpenAlexW2986857312

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.