Evidence map›Paper›PMID 31678471›Full record

ArticleMechanisms of development2019

Regulation of Numb during planar cell polarity establishment in the Drosophila eye.

Pedro M Domingos, Andreas Jenny, Keon F Combie, David Del Alamo, Marek Mlodzik, Hermann Steller, Bertrand Mollereau

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mechanisms of development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Pedro M DomingosInstituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República, Oeiras 2780-157, Portugal; Strang Laboratory of Apoptosis and Cancer Research, The Rockefeller University, Box 252, 1230 York Avenue, New York, NY 10065, USA. Electronic address: domingp@itqb.unl.pt.
Andreas JennyAlbert Einstein College of Medicine, 1300 Morris Park Avenue, Chanin Building, Room 503, Bronx NY10461, USA; Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Keon F CombieStrang Laboratory of Apoptosis and Cancer Research, The Rockefeller University, Box 252, 1230 York Avenue, New York, NY 10065, USA.
David Del AlamoDepartment of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; European Molecular Biology Organization, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
Marek MlodzikDepartment of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Hermann StellerStrang Laboratory of Apoptosis and Cancer Research, The Rockefeller University, Box 252, 1230 York Avenue, New York, NY 10065, USA.
Bertrand MollereauStrang Laboratory of Apoptosis and Cancer Research, The Rockefeller University, Box 252, 1230 York Avenue, New York, NY 10065, USA; Université de Lyon, ENSL, UCBL, CNRS, LBMC, 46 Allée d'Italie, 69007 Lyon, France. Electronic address: bertrand.mollereau@ens-lyon.fr.
Rockefeller University · USAlbert Einstein College of Medicine · USEuropean Molecular Biology Organization · DEIcahn School of Medicine at Mount Sinai · USUniversité Claude Bernard Lyon 1 · FR

Funding

Retinal Patterning During Eye DevelopmentR01EY013256 · NEI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI Marek Mlodzik · 2001 to 2026
$10.0M
Wnt/Frizzled-PCP signaling in development and diseaseR35GM127103 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Marek Mlodzik · 2018 to 2026
$5.6M
Proteasome Regulation and Function in Cellular RemodelingR01GM060124 · NIGMS · ROCKEFELLER UNIVERSITY · PI STELLER, HERMANN · 1999 to 2018
$5.4M
Late photoreceptor cell differentation in D melanogasterR01EY014025 · NEI · ROCKEFELLER UNIVERSITY · PI MOLLEREAU, BERTRAND · 2002 to 2005
$1.2M
NEI NIH HHS R01 EY013256NEI NIH HHS R01 EY014025NIGMS NIH HHS R01 GM060124NIGMS NIH HHS R35 GM127103
6 · The paper itself

Abstract

The establishment of planar cell polarity (PCP) in the Drosophila eye requires correct specification of the R3/R4 pair of photoreceptor cells, determined by a Frizzled mediated signaling event that specifies R3 and induces Delta to activate Notch signaling in the neighboring cell, specifying it as R4. Here, we investigated the role of the Notch signaling negative regulator Numb in the specification of R3/R4 fates and PCP establishment in the Drosophila eye. We observed that Numb is transiently upregulated in R3 at the time of R3/R4 specification. This regulation of Numb levels in developing photoreceptors occurs at the post-transcriptional level and is dependent on Dishevelled, an effector of Frizzled signaling, and Lethal Giant Larva. We detected PCP defects in cells homozygous for numb

Indexed as

Cell PolarityAnimalsChromosomesDrosophila melanogasterDrosophila ProteinsEyeGene Expression Regulation, DevelopmentalJuvenile HormonesMaleMutationPhenotypeUp-RegulationDrosophila ProteinsJuvenile Hormonesnumb protein, DrosophilaDrosophila eye developmentFatNumbPlanar cell polarity

Identifiers

PMID31678471
PMCPMC6980312
OpenAlexW2986945997

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.