Evidence map›Paper›PMID 31678373›Full record

ReviewNeuroscience letters2020

The effects of developmental and current niches on oligodendrocyte precursor dynamics and fate.

Linda L Boshans, Amin Sherafat, Akiko Nishiyama

Abstract readReview
In one paragraph

Review in Neuroscience letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Life-long oligodendrocyte development and plasticity.Seminars in cell & developmental biology · 2021
    Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Linda L BoshansDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT, 06269, USA.
Amin SherafatDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT, 06269, USA.
Akiko NishiyamaDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT, 06269, USA; Institute for Systems Genomics, University of Connecticut, USA; Institute for Brain and Cognitive Science, University of Connecticut, USA. Electronic address: akiko.nishiyama@uconn.edu.

Funding

Inflammation and NG2 Cell DifferentiationR01NS073425 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI NISHIYAMA, AKIKO · 2011 to 2021
$3.3M
Heterogeneity of NG2 Glial CellsR01NS074870 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI NISHIYAMA, AKIKO · 2012 to 2016
$1.7M
NINDS NIH HHS R01 NS073425NINDS NIH HHS R01 NS074870
6 · The paper itself

Abstract

Oligodendrocyte precursor cells (OPCs), whose primary function is to generate myelinating oligodendrocytes, are distributed widely throughout the developing and mature central nervous system. They originate from several defined subdomains in the embryonic germinal zones at different developmental stages and in the adult. While many phenotypic differences have been observed among OPCs in different anatomical regions and among those arising from different germinal zones, we know relatively little about the molecular and cellular mechanisms by which the historical and current niches shape the behavior of oligodendrocyte lineage cells. This minireview will discuss how the behavior of oligodendrocyte lineage cells is influenced by the developmental niches from which subpopulations of OPCs emerge, by the current niches surrounding OPCs in different regions, and in pathological states that cause deviations from the normal density of oligodendrocyte lineage cells and myelin.

Indexed as

AnimalsBrainCell DifferentiationCell LineageHumansOligodendrocyte Precursor CellsOligodendrogliaSpinal CordAstrocyteDevelopmentMyelinNG2NicheOligodendrocyte precursorPDGFProliferation

Identifiers

PMID31678373
PMCPMC6933750

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.