ArticleNeuroscience2019
Increased Type I and Decreased Type II Hair Cells after Deletion of Sox2 in the Developing Mouse Utricle.
Article in Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Pou4f3 Deficiency Obstructs the Subtype Differentiation of Vestibular Hair Cells.Neuroscience bulletin · 2026Article
- A Regional Ultrastructural Analysis of the Cellular and Synaptic Architecture of the Mouse Vestibular Periphery, With Reference to the Chinchilla.The Journal of comparative neurology · 2025Article
- Pharmacological regeneration of sensory hair cells restores afferent innervation and vestibular function.The Journal of clinical investigation · 2024Article
- TMC function, dysfunction, and restoration in mouse vestibular organs.Frontiers in neurology · 2024Article
- Maturation of type I and type II rat vestibular hair cellsFrontiers in cell and developmental biology · 2024Article
- Defining developmental trajectories of prosensory cells in human inner ear organoids at single-cell resolution.Development (Cambridge, England) · 2023Article
- Comparative assessment of Fgf's diverse roles in inner ear development: A zebrafish perspective.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- Dynamic patterns of YAP1 expression and cellular localization in the developing and injured utricle.Scientific reports · 2021Article
- Canonical Wnt Signaling Pathway on Polarity Formation of Utricle Hair Cells.Neural plasticity · 2021Article
- Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
The vestibular system of the inner ear contains Type I and Type II hair cells (HCs) generated from sensory progenitor cells; however, little is known about how the HC subtypes are formed. Sox2 (encoding SRY-box 2) is expressed in Type II, but not in Type I, HCs. The present study aimed to investigate the role of SOX2 in cell fate determination in Type I vs. Type II HCs. First, we confirmed that Type I HCs developed from Sox2-expressing cells through lineage tracing of Sox2-positive cells using a CAG-tdTomato reporter mouse crossed with a Sox2-CreER mouse. Then, Sox2 loss of function was induced in HCs, using Sox2
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