ArticleNeuroImage2020
The genetics of cortical myelination in young adults and its relationships to cerebral surface area, cortical thickness, and intelligence: A magnetic resonance imaging study of twins and families.
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex.Nature communications · 2022Pooled it
- Cortical thickness, surface area, and multisite pain: distinct patterns by sex in adolescence.Biology of sex differences · 2026Article
- Socioeconomic context influences the heritability of child cortical structure.Communications biology · 2025Article
- Socioeconomic context influences the heritability of child cortical structure.medRxiv : the preprint server for health sciences · 2025Article
- Human Sensorimotor Beta Event Characteristics and Aperiodic Signal Are Highly Heritable.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Myelination and excitation-inhibition balance synergistically shape structure-function coupling across the human cortex.Nature communications · 2023Article
- The intracortical myelin content of impulsive choices: results from T1- and T2-weighted MRI myelin mapping.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Genetic and Environmental Variation in Continuous Phenotypes in the ABCD Study®.Behavior genetics · 2023Article
- Stress and the brain: Emotional support mediates the association between myelination in the right supramarginal gyrus and perceived chronic stress.Neurobiology of stress · 2023Article
- T1w/T2w Ratio and Cognition in 9-to-11-Year-Old Children.Brain sciences · 2022Article
- Twin studies to GWAS: there and back again.Trends in cognitive sciences · 2021Review
- Neurodevelopment of the association cortices: Patterns, mechanisms, and implications for psychopathology.Neuron · 2021Review
- Regional White Matter Scaling in the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Preference uncertainty accounts for developmental effects on susceptibility to peer influence in adolescence.Nature communications · 2021Article
- Article
- The Heritability of Cortical Folding: Evidence from the Human Connectome Project.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Constructing and evaluating a cortical surface atlas and analyzing cortical sex differences in young Chinese adults.Human brain mapping · 2020Article
- Brain patterns linked to neuropsychiatric genetic risk mirror those seen in disease.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The cerebral cortex contains a significant quantity of intracortical myelin, but the genetics of cortical myelination (CM) in humans is not well understood. Relatively novel MRI-derived measures now enable the investigation of cortical myelination in large samples. In this study, we use a genetically-informative neuroimaging sample of 1096 young adult subjects from the Human Connectome Project in order to investigate genetic and environmental variation in CM and its relationships with cerebral surface area (SA) and cortical thickness (CT). We found that genetic factors account for approximately 50% of the observed individual differences in mean cortical myelin, 75% of the variation in total SA, and 85% of the variance in global mean CT. Although significant genetic influences were found throughout the cortex, both CM and SA demonstrated a posterior predominance, with disproportionately strong effects in the parietal and occipital lobes and significantly overlapping heritability maps (p < 0.001). Yet despite showing similar spatial heritability patterns, we found evidence that CM is genetically independent from SA at both global and vertex levels; genetically-mediated relationships between CM and CT were similarly small in magnitude. We also found small but statistically significant genetic associations between NIH Toolbox Total Cognition score and CM in the temporal lobe and insula. SA-cognition and CT-cognition correlations were less widespread compared to CM and both patterns were similar to those reported in prior studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.