Evidence map›Paper›PMID 31678055›Full record

ArticleThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

The effectiveness of the national hepatitis B vaccination program 25 years after its introduction in Iran: a historical cohort study.

Mohsen Moghadami, Nazanin Dadashpour, Ali Mohammad Mokhtari, Mostafa Ebrahimi, Alireza Mirahmadizadeh

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Article in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  17. Prediction of Hepatitis disease using ensemble learning methods.Journal of preventive medicine and hygiene · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohsen MoghadamiShiraz University of Medical Sciences, Clinical Microbiology Research Center, Shiraz, Iran. Electronic address: moghadami@sums.ac.ir.
Nazanin DadashpourShiraz University of Medical Sciences, School of Medicine, Department of Internal Medicine, Shiraz, Iran. Electronic address: nazanindadashpour1@gmail.com.
Ali Mohammad MokhtariShiraz University of Medical Sciences, Student Research Committee, Shiraz, Iran. Electronic address: mokhtariam67@yahoo.com.
Mostafa EbrahimiShiraz University of Medical Sciences, Department of Health, Shiraz, Iran. Electronic address: ebrahimi.m.cdc@gmail.com.
Alireza MirahmadizadehShiraz University of Medical Sciences, Non-communicable diseases research center, Shiraz, Iran. Electronic address: mirahmadia@sums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHepatitis B virus (HBV) is responsible for one of the most common human viral infections. An estimated 257 million people are living with chronic HBV infection worldwide, and mortality has reached 900,000 deaths in recent years. In 2001, the World Health Organization reported a prevalence of chronic hepatitis B infection in Iran between 2-7%.

objectiveTo assess the effect of the national HBV mass vaccination program after 25 years.

methodsA retrospective cohort study was conducted in vaccinated and unvaccinated people according to the year of birth. Blood samples were obtained from each enrolled person and data about demographic variables, and medical and vaccination history were collected using a standardized questionnaire. Persons were considered uninfected if they were negative for both HBsAg and anti-HBc. Also, Vaccine effectiveness was measured by calculating the risk of disease among vaccinated and unvaccinated persons and defining the percentage risk reduction of infection in the vaccinated group.

resultsA total of 2720 persons were interviewed. The rate of HBV breakthrough infection among the vaccinated group was significantly lower than in unvaccinated group. One hundred ninety-four cases with positive HBV markers of infection were identified. The risk ratio of HBV infection was 0.71, 95% CI: 0.54-0.94 (vaccinated/unvaccinated). The estimated vaccination effectiveness against Hepatitis B infection was 29% (95% CI: 6%-46%).

conclusionsIran has successfully combined hepatitis B vaccination into regular immunization programs. The WHO goal of reducing HBsAg prevalence to an equivalent of 1% by 2020 has been reached. With respect to vaccination effectiveness and low prevalence of the disease in the country, catch-up hepatitis B vaccination programs for adolescents can guarantee the immunity of the population.

Indexed as

AdolescentAdultHepatitis BHepatitis B, ChronicHepatitis B VaccinesHumansImmunization ProgramsIranMaleMiddle AgedPrevalenceRetrospective StudiesSurveys and QuestionnairesVaccinationYoung AdultHepatitis B VaccinesEffectiveness researchHepatitis BVaccination

Identifiers

PMID31678055
PMCPMC9428176

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.