ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2019
Individualized clinical management of patients at risk for Alzheimer's dementia.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer's Disease and MCI: A Review.International journal of molecular sciences · 2023Pooled it
- Prevalence of Behavioral and Psychological Symptoms of Dementia in Community-Dwelling Dementia Patients: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Trial
- Precision Medicine Approach to Alzheimer's Disease: Successful Pilot Project.Journal of Alzheimer's disease : JAD · 2022Trial
- KetoFLEX 12/3 Diet and Cognitive Health: A Precision-Nutrition Perspective on Mechanisms, Emerging Evidence, and Future Directions.Nutrients · 2026Review
- Standardizing the Measurement and Definition of Post-Stroke Cognitive Impairment: Implications for Stroke Recovery and Rehabilitation.Neurorehabilitation and neural repair · 2026Review
- AI in geriatric psychiatry: precision meets human experience.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Multidomain therapy for Alzheimer's disease: a scoping review of cognitive decline trials.Molecular neurodegeneration · 2025Article
- Patient management pathways in dementia - Resource utilisation, diagnosis and drug treatment in the Stockholm region, Sweden.The journal of prevention of Alzheimer's disease · 2025Observational
- Practicality of a patient self-assessment checklist to manage dementia risk factors in GP practices.Scientific reports · 2025Article
- Alzheimer disease seen through the lens of sex and gender.Nature reviews. Neurology · 2025Review
- Older adult's acceptance and uptake of referral after screening for cognitive impairment: a cross-sectional study in China.BMC geriatrics · 2025Article
- Prevalence and population attributable fractions of potentially modifiable risk factors for dementia in Canada: A cross-sectional analysis of the Canadian Longitudinal Study on Aging.Canadian journal of public health = Revue canadienne de sante publique · 2024Article
- Association between Multi-Domain Lifestyle and Objective Cognitive Impairment in Elderly People with SCD and MCI in Chinese Communities.Healthcare (Basel, Switzerland) · 2024Article
- Association between experiencing low healthcare quality and developing dementia.Journal of the American Geriatrics Society · 2024Article
- Neurocognitive Effects of an Online Brain Health Program and Weekly Telehealth Support Group in Older Adults with Subjective Memory Loss: A Pilot Study.Geriatrics (Basel, Switzerland) · 2024Article
- Bibliometric analysis of research trends on factors affecting older adults with mild cognitive impairment.Frontiers in neurology · 2024Review
- Knowledge of Risk Factors for Dementia and Attitudes on a Dementia Prevention Program by Age and Ethnicity in Arizona.JAR life · 2024Article
- Sex-based differences in effector cells of the adaptive immune system during Alzheimer's disease and related dementias.Neurobiology of disease · 2023Review
- A how-to guide for a precision medicine approach to the diagnosis and treatment of Alzheimer's disease.Frontiers in aging neuroscience · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 15 institutions in 2 countries.
Funding
Abstract
introductionMultidomain intervention for Alzheimer's disease (AD) risk reduction is an emerging therapeutic paradigm.
methodsPatients were prescribed individually tailored interventions (education/pharmacologic/nonpharmacologic) and rated on compliance. Normal cognition/subjective cognitive decline/preclinical AD was classified as Prevention. Mild cognitive impairment due to AD/mild-AD was classified as Early Treatment. Change from baseline to 18 months on the modified Alzheimer's Prevention Cognitive Composite (primary outcome) was compared against matched historical control cohorts. Cognitive aging composite (CogAging), AD/cardiovascular risk scales, and serum biomarkers were secondary outcomes.
resultsOne hundred seventy-four were assigned interventions (age 25-86). Higher-compliance Prevention improved more than both historical cohorts (P = .0012, P < .0001). Lower-compliance Prevention also improved more than both historical cohorts (P = .0088, P < .0055). Higher-compliance Early Treatment improved more than lower compliance (P = .0007). Higher-compliance Early Treatment improved more than historical cohorts (P < .0001, P = .0428). Lower-compliance Early Treatment did not differ (P = .9820, P = .1115). Similar effects occurred for CogAging. AD/cardiovascular risk scales and serum biomarkers improved. DISCUSSION: Individualized multidomain interventions may improve cognition and reduce AD/cardiovascular risk scores in patients at-risk for AD dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.