SynthesisWorld journal of surgical oncology2019
Prognostic role of the advanced lung cancer inflammation index in cancer patients: a meta-analysis.
Synthesis in World journal of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical significance of the advanced lung cancer inflammation index in gastrointestinal cancer patients: a systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Prognostic significance of Rab27 expression in solid cancer: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Trial
- Evaluation of the Naples Prognostic Score in Patients with Head and Neck Squamous Cell Carcinoma.Nutrients · 2026Article
- Concurrent Chemoradiotherapy with Daily Low-Dose Carboplatin in Older Patients with Unresectable Locally Advanced Non-Small-Cell Lung Cancer: Clinical Outcomes and Prognostic Significance of Systemic Inflammation Markers.Current oncology (Toronto, Ont.) · 2026Article
- Association between advanced lung cancer inflammation index and postoperative mortality in lung cancer patients: a retrospective cohort study.European journal of medical research · 2025Article
- Advanced lung cancer inflammation index and all-cause mortality in critically ill patients with sepsis: analysis of the MIMIC-IV database.BMC infectious diseases · 2025Observational
- From biomarker to clinical utility: translating the advanced lung cancer inflammation index into a machine learning-driven risk stratification tool for colorectal cancer.Journal of translational medicine · 2025Article
- Combined impact of nutritional and inflammatory status and depressive symptoms on mortality following hysterectomy.BMC women's health · 2025Article
- Nutritional-inflammatory balance assessed by advanced lung cancer inflammation index and its association with all-cause mortality in coronary heart disease : a retrospective cohort study.Journal of health, population, and nutrition · 2025Article
- Significance of Platinum-Based Chemotherapy With Programmed Death-1 Blockade in Limited Disease Small Cell Lung Cancer: A Retrospective Study.Thoracic cancer · 2025Article
- Prognostic value of advanced lung cancer inflammation index in heart failure patients: A comprehensive analysis.ESC heart failure · 2025Article
- Association between advanced lung cancer inflammation index and distant metastasis in breast cancer: a retrospective cohort study.Frontiers in oncology · 2025Article
- The comparison of the prognostic value of different inflammation-related indicators in patients with oral squamous cell carcinoma.Frontiers in genetics · 2025Article
- Association between Advanced Lung Cancer Inflammation Index and 30-day mortality in patients with spontaneous intracerebral hemorrhage: a retrospective cohort study.Frontiers in neurology · 2025Article
- Association between a new indicator with non-alcoholic fatty liver and liver fibrosis in US adults: findings from NHANES 2017-2018.Translational gastroenterology and hepatology · 2025Article
- Combined effects of nutrition, inflammatory status, and sleep quality on mortality in cancer survivors.BMC cancer · 2024Article
- Prognostic Significance of the Advanced Lung Cancer Inflammation Index in Metastatic Small Cell Lung Cancer: A Retrospective Analysis of 96 Patients.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Combined influence of nutritional and inflammatory status and breast cancer: findings from the NHANES.BMC public health · 2024Article
- Advanced Lung Cancer Inflammation Index: A Novel Comprehensive Biomarker of Host Status for Patients with Metastatic Colorectal Cancer.Journal of the anus, rectum and colon · 2024Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammation plays a critical role in the development and progression of cancers. The advanced lung cancer inflammation index (ALI) is thought to be able to reflect systemic inflammation better than current biomarkers. However, the prognostic significance of the ALI in various types of cancer remains unclear. Our meta-analysis aimed to comprehensively investigate the relationship between the ALI and oncologic outcomes to help physicians better assess the prognosis of cancer patients.
methodsThe PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases were searched for relevant studies. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated and pooled from the included studies. Furthermore, a sensitivity analysis was performed to evaluate the reliability of the articles. Finally, Begg's test, Egger's test, and the funnel plot were applied to assess the significance of publication bias.
resultsIn total, 1736 patients from nine studies were included in our meta-analysis. The median cutoff value for the ALI was 23.2 (range, 15.5-37.66) in the analyzed studies. The meta-analysis showed that there was a statistically significant relationship between a low ALI and worse overall survival (OS) in various types of cancer (HR = 1.70, 95% CI = 1.41-1.99, P < 0.001). Moreover, results from subgroup meta-analysis showed that the ALI had a significant prognostic value in non-small cell lung cancer, small cell lung cancer, colorectal cancer, head and neck squamous cell carcinoma, and diffuse large B cell lymphoma (P < 0.05 for all).
conclusionsThese results showed that a low ALI was associated with poor OS in various types of cancer, and the ALI could act as an effective prognostic biomarker in cancer patients.
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