ArticleNeuroImage. Clinical2019
Corticolimbic circuit structure moderates an association between early life stress and later trait anxiety.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Neural correlates of resilience to trauma during adolescence: A multi-modal study.JCPP advances · 2026Article
- Article
- Predicting stress response trajectories: Differential contributions of limbic and prefrontal regions to cortisol and affective responses.Translational psychiatry · 2026Article
- Prefrontal cortex development and its implications in mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Neurobiology and systems biology of stress resilience.Physiological reviews · 2024Review
- Atypical brain structural connectivity and social cognition in childhood maltreatment and peer victimisation.BMC psychiatry · 2024Article
- Neurostructural Consequences of Obstetric Brachial Plexus Palsy in Childhood.Neuroscience insights · 2024Article
- From mother to child: How intergenerational transfer is reflected in similarity of corticolimbic brain structure and mental health.Developmental cognitive neuroscience · 2023Article
- Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity on therapeutic efficacy.Frontiers in endocrinology · 2022Article
- White matter integrity moderates the relation between experienced childhood maltreatment and fathers' behavioral response to infant crying.Developmental psychobiology · 2021Article
- Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood.Clinical epigenetics · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Childhood adversity is associated with a wide range of negative behavioral and neurodevelopmental consequences. However, individuals vary substantially in their sensitivity to such adversity. Here, we examined how individual variability in structural features of the corticolimbic circuit, which plays a key role in emotional reactivity, moderates the association between childhood adversity and later trait anxiety in 798 young adult university students. Consistent with prior research, higher self-reported childhood adversity was significantly associated with higher self-reported trait anxiety. However, this association was attenuated in participants with higher microstructural integrity of the uncinate fasciculus and greater thickness of the orbitofrontal cortex. These structural properties of the corticolimbic circuit may capture a neural profile of relative resiliency to early life stress, especially against the negative effects of childhood adversity on later trait anxiety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.