ArticleBreast (Edinburgh, Scotland)2020
Sonography with vertical orientation feature predicts worse disease outcome in triple negative breast cancer.
Article in Breast (Edinburgh, Scotland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 22 citations in OpenAlex.
- Ultrasound-based multiregional radiomics nomogram for predicting recurrence in HER2-positive breast cancer.BMC medical imaging · 2026Article
- A nomogram to predict disease-free survival in patients with residual triple-negative breast cancer after neoadjuvant chemotherapy based on clinicopathological and sonographic features.Translational cancer research · 2026Article
- Article
- Diagnostic value of ultrasound radiomic features in differentiating benign and malignant breast lesions.Journal of ultrasound · 2025Article
- Article
- A diagnostic test of two-dimensional ultrasonic feature extraction based on artificial intelligence combined with blood flow Adler classification and contrast-enhanced ultrasound for predictingTranslational cancer research · 2025Article
- Machine learning-based ultrasound radiomics for predicting risk of recurrence in breast cancer.Frontiers in oncology · 2025Article
- Nomograms for predicting recurrence of HER2-positive breast cancer with different HR status based on ultrasound and clinicopathological characteristics.Cancer medicine · 2024Article
- The utility of quantifying the orientation of breast masses in ultrasound imaging.Scientific reports · 2024Article
- Does a 40% Cut-off Point for Ki-67 Expression Have a Role in Identifying the Development of Distant Metastasis Within 2 Years in Locally Advanced Triple Negative Breast Cancer Patients?European journal of breast health · 2023Article
- Progress in research on ultrasound radiomics for predicting the prognosis of breast cancer.Cancer innovation · 2023Review
- Ultrasound features for prediction of long-term outcomes of women with primary breast cancer <20 mm.Frontiers in oncology · 2023Article
- Survival outcome assessment for triple-negative breast cancer: a nomogram analysis based on integrated clinicopathological, sonographic, and mammographic characteristics.European radiology · 2022Article
- Nomograms predicting recurrence in patients with triple negative breast cancer based on ultrasound and clinicopathological features.The British journal of radiology · 2022Article
- Predictive Value of Ultrasound Characteristics for Disease-Free Survival in Breast Cancer.Diagnostics (Basel, Switzerland) · 2022Article
- Prediction for pathological and immunohistochemical characteristics of triple-negative invasive breast carcinomas: the performance comparison between quantitative and qualitative sonographic feature analysis.European radiology · 2022Article
- Calcification, Posterior Acoustic, and Blood Flow: Ultrasonic Characteristics of Triple-Negative Breast Cancer.Journal of healthcare engineering · 2022Article
- Development and External Validation of a Simple-To-Use Dynamic Nomogram for Predicting Breast Malignancy Based on Ultrasound Morphometric Features: A Retrospective Multicenter Study.Frontiers in oncology · 2022Article
- Association of machine learning ultrasound radiomics and disease outcome in triple negative breast cancer.American journal of cancer research · 2022Article
- Radiomics features on ultrasound imaging for the prediction of disease-free survival in triple negative breast cancer: a multi-institutional study.The British journal of radiology · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTriple negative breast cancer (TNBC) is a heterogenous disease and associated with unfavorable outcomes. The role of sonographic features and its association with disease outcome in TNBC is uncertain. Our study aimed to determine the prognosis predictive value of sonographic features in TNBC.
methodsWomen with TNBC patients treated between January 2009 and December 2015 were retrospectively included. Patients' clinic-pathological, sonographic features, recurrence-free survival (RFS), and breast cancer-specific survival (BCSS) events were reviewed and analyzed. Kaplan-Meier analysis and multivariable Cox regression were used to determine the prognostic factors in TNBC.
resultsA total of 433 TNBC patients were included. With a median follow-up of 4.8 years, 58 (13.4%) RFS and 35(8.1%) BCSS events were detected. Besides lymphatic vascular invasion (LVI), nuclear grade III, tumor >2.0 cm, and positive axillary lymph node (ALN), multivariable analysis found that vertical orientation in ultrasound imaging was independently associated with worse RFS (Hazard Ratio (HR) = 3.238; 95% Confidential Interval (CI), 1.661-6.312; P = 0.001) and BCSS (HR = 7.028; 95% CI, 3.199-15.436; P < 0.001). TNBC with vertical orientation in ultrasound imaging had higher ALN metastasis burden than those with sonographic parallel features (2.7 ± 1.0 vs 1.5 ± 0.2, P = 0.003).
conclusionsTNBC presenting with vertical orientation in ultrasound imaging was associated with worse disease outcome and a greater number of ALN metastasis.
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