Evidence map›Paper›PMID 31677478›Full record

ArticleiScience2019

Visualizing Dynamic Performance of Lipid Droplets in a Parkinson's Disease Model via a Smart Photostable Aggregation-Induced Emission Probe.

Lihua Li, Fan Zhou, Qun Gao, Yao Lu, Xingyi Xu, Rong Hu, Zhiming Wang, Mingying Peng, Zhongmin Yang, Ben Zhong Tang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Lipid Droplet-Mitochondria Contacts in Health and Disease.International journal of molecular sciences · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Lihua LiState Key Laboratory of Luminescent Materials and Devices, Applied Techniques School of Materials Science and Engineering and Center for Aggregation-Induced Emission, Guangdong Provincial Key Laboratory of Fiber Laser Materials, School of Materials Science and Engineering, School of Physics, South China University of Technology, 381 Wushan Road, Guangzhou 510640, China.
Fan ZhouState Key Laboratory of Luminescent Materials and Devices, Applied Techniques School of Materials Science and Engineering and Center for Aggregation-Induced Emission, Guangdong Provincial Key Laboratory of Fiber Laser Materials, School of Materials Science and Engineering, School of Physics, South China University of Technology, 381 Wushan Road, Guangzhou 510640, China.
Qun GaoDepartment of Neurosurgery, Beijing Hospital, National Center of Gerontology, Graduate School of Peking Union Medical College, Beijing 100005, China.
Yao LuDepartment of Orthopedics, Zhujiang Hospital, Southern Medical University, 253 Gongye Road, Guangzhou 510282, China.
Xingyi XuState Key Laboratory of Luminescent Materials and Devices, Applied Techniques School of Materials Science and Engineering and Center for Aggregation-Induced Emission, Guangdong Provincial Key Laboratory of Fiber Laser Materials, School of Materials Science and Engineering, School of Physics, South China University of Technology, 381 Wushan Road, Guangzhou 510640, China.
Rong HuState Key Laboratory of Luminescent Materials and Devices, Applied Techniques School of Materials Science and Engineering and Center for Aggregation-Induced Emission, Guangdong Provincial Key Laboratory of Fiber Laser Materials, School of Materials Science and Engineering, School of Physics, South China University of Technology, 381 Wushan Road, Guangzhou 510640, China.
Zhiming WangState Key Laboratory of Luminescent Materials and Devices, Applied Techniques School of Materials Science and Engineering and Center for Aggregation-Induced Emission, Guangdong Provincial Key Laboratory of Fiber Laser Materials, School of Materials Science and Engineering, School of Physics, South China University of Technology, 381 Wushan Road, Guangzhou 510640, China. Electronic address: wangzhiming@scut.edu.cn.
Mingying PengState Key Laboratory of Luminescent Materials and Devices, Applied Techniques School of Materials Science and Engineering and Center for Aggregation-Induced Emission, Guangdong Provincial Key Laboratory of Fiber Laser Materials, School of Materials Science and Engineering, School of Physics, South China University of Technology, 381 Wushan Road, Guangzhou 510640, China. Electronic address: pengmingying@scut.edu.cn.
Zhongmin YangState Key Laboratory of Luminescent Materials and Devices, Applied Techniques School of Materials Science and Engineering and Center for Aggregation-Induced Emission, Guangdong Provincial Key Laboratory of Fiber Laser Materials, School of Materials Science and Engineering, School of Physics, South China University of Technology, 381 Wushan Road, Guangzhou 510640, China. Electronic address: yangzm@scut.edu.cn.
Ben Zhong TangState Key Laboratory of Luminescent Materials and Devices, Applied Techniques School of Materials Science and Engineering and Center for Aggregation-Induced Emission, Guangdong Provincial Key Laboratory of Fiber Laser Materials, School of Materials Science and Engineering, School of Physics, South China University of Technology, 381 Wushan Road, Guangzhou 510640, China; Department of Chemistry and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China. Electronic address: tangbenz@ust.hk.
South China University of Technology · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNHong Kong University of Science and Technology · HKZhujiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a complex neurodegenerative disease affected by diverse factors, and lipid droplets (LDs) are increasingly recognized as major players in PD because of their relevance to neuron activity. However, long-term dynamic changes of LDs and their relative activity remain unclear. Here, an aggregation-induced emission (AIE) probe named 2-DPAN was prepared and employed to visualize dynamic processes of LDs in a 6-hydroxydopamine model of PD for the first time, and LDs' accumulation-peak/plateau-decrease were confirmed. We further found a close relationship between LDs and variation in mitochondrial activity. Strikingly, the progression of cell death was accelerated by lipase, whereas pre-stimulation of LDs by unsaturated fatty acid-oleic acid decreased the death process by inhibiting excessive reactive oxygen species (ROS) and fatty acid production, thereby protecting mitochondria. The utilization of 2-DPAN demonstrates the importance of LDs in neuronal homeostasis, and effective tuning of LDs may prevent or inhibit PD progression.

Indexed as

Chemical SynthesisDiseaseMaterials Design

Identifiers

PMID31677478
PMCPMC6838505
OpenAlexW2981126649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.