Evidence map›Paper›PMID 31677359›Full record

ArticleCancer science2020

Immunological features of a lung cancer patient achieving an objective response with anti-programmed death-1 blockade therapy.

Toshiko Kamata, Shigetoshi Yoshida, Mariko Takami, Fumie Ihara, Hiroko Yoshizawa, Takahide Toyoda, Yuichiro Takeshita, Seiichi Nobuyama, Yukiko Kanetsuna, Tetsuo Sato and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Toshiko KamataDepartment of Thoracic Surgery, School of Medicine, International University of Health and Welfare, Atami Hospital, Atami, Japan.
Shigetoshi YoshidaDepartment of Thoracic Surgery, School of Medicine, International University of Health and Welfare, Atami Hospital, Atami, Japan.ORCID https://orcid.org/0000-0001-5571-886X
Mariko TakamiDepartment of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Fumie IharaDepartment of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Hiroko YoshizawaDepartment of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Takahide ToyodaDepartment of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yuichiro TakeshitaDepartment of Respirology, Atami Hospital, International University of Health and Welfare, Atami, Japan.
Seiichi NobuyamaDepartment of Respirology, Atami Hospital, International University of Health and Welfare, Atami, Japan.
Yukiko KanetsunaDepartment of Clinical Pathology, Atami Hospital, International University of Health and Welfare, Atami, Japan.
Tetsuo SatoDepartment of Respirology, Atami Hospital, International University of Health and Welfare, Atami, Japan.
Ichiro YoshinoDepartment of General Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Shinichiro MotohashiDepartment of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID https://orcid.org/0000-0002-9332-3129

Funding

International University of Health and Welfare, School of MedicineMinistry of Education, Culture, Sports, Science and Technology 18H02892
6 · The paper itself

Abstract

The role of immune checkpoint inhibitors in metastatic lung cancer has been established in recent years and the pretherapeutic profiles of the tumor microenvironment in responders have been increasingly reported. The role of salvage surgery and the immune profiles of the posttherapeutic specimens in patients achieving an objective response have rarely been studied. We report a case of metastatic lung cancer treated by anti-programmed death-1 Ab followed by surgical resection. The immune status of the tumor was assessed, showing germinal center formation, memory B cell infiltration, and a high frequency of interferon gamma -secreting T cells.

Indexed as

AgedAntibodies, MonoclonalB-LymphocytesGerminal CenterHumansLung NeoplasmsMaleProgrammed Cell Death 1 ReceptorT-LymphocytesTumor MicroenvironmentAntibodies, MonoclonalProgrammed Cell Death 1 Receptoranti-PD-1 antibodyimmunotherapylung cancersurgerytumor-infiltrating lymphocyte

Identifiers

PMID31677359
PMCPMC6942425

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.