Evidence map›Paper›PMID 31677239›Full record

ArticleChemMedChem2019

The Activity of Small Urea-γ-AApeptides Toward Gram-Positive Bacteria.

Ma Su, Yan Shi, Minghui Wang, Ruixuan Gao, Jianfeng Wu, Hai Xu, Chuanwu Xi, Jianfeng Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ma SuDepartment of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL 33620, USA.
Yan ShiDepartment of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL 33620, USA.
Minghui WangDepartment of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL 33620, USA.
Ruixuan GaoDepartment of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL 33620, USA.
Jianfeng WuDepartment of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.
Hai XuCollege of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.
Chuanwu XiDepartment of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.
Jianfeng CaiDepartment of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL 33620, USA.ORCID 0000-0003-3106-3306

Funding

Requesting HPLC for the project of "Alpha-AApeptides as a Novel Class of Antimicrobial Biomaterials"R01GM112652 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI CAI, JIANFENG · 2015 to 2019
$1.5M
Thermo-detachable anti-biofilm polymer coatingsR21DE020908 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KURODA, KENICHI, XI, CHUANWU · 2010 to 2011
$423k
NIDCR NIH HHS R21 DE020908NIGMS NIH HHS R01 GM112652NIH 1RO1GM112652NSF 1708500
6 · The paper itself

Abstract

Host Defense Peptides (HDPs) have gained considerable interest due to the omnipresent threat of bacterial infection as a serious public health concern. However, development of HDPs is impeded by several drawbacks, such as poor selectivity, susceptibility to proteolytic degradation, low-to-moderate activity and requiring complex syntheses. Herein we report a class of lipo-linear α/urea-γ-AApeptides with a hybrid backbone and low molecular weight. The heterogeneous backbone not only enhances chemodiversity, but also shows effective antimicrobial activity against Gram-positive bacteria and is capable of disrupting bacterial membranes and killing bacteria rapidly. Given their low molecular weight and ease of access via facile synthesis, they could be practical antibiotic agents.

Indexed as

AmidesAmino Acid SequenceAnti-Bacterial AgentsAntimicrobial Cationic PeptidesBacterial InfectionsCell Membrane PermeabilityDrug Evaluation, PreclinicalGram-Negative BacteriaGram-Positive BacteriaHumansLipopeptidesMicrobial Sensitivity TestsMolecular StructureMolecular WeightPeptidesPeptidomimeticsAmidesAnti-Bacterial AgentsAntimicrobial Cationic Peptidesgamma-AApeptideLipopeptidesPeptidesPeptidomimeticsUreaantibioticsdrug resistanceMRSApeptidessmall molecule

Identifiers

PMID31677239
PMCPMC6939633

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.