ArticleJournal of tissue engineering and regenerative medicine2019
Directional topography gradients drive optimum alignment and differentiation of human myoblasts.
Article in Journal of tissue engineering and regenerative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Functionalized bio-patches for intra-abdominal applications.iScience · 2026Review
- Shear-Induced Patterning of Decellularized Skeletal Muscle Extracellular Matrix for Enhanced Myogenesis.Advanced healthcare materials · 2025Article
- Functionalized Multi-Walled Carbon Nanotube Enhanced Myogenic Differentiation for Aligned Topography-Induced Skeletal Muscle Engineering.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Harnessing the power of physicochemical material property screening to direct breast epithelial and breast cancer cells.Bioactive materials · 2025Article
- Developing Porous Fibrin Scaffolds with Tunable Anisotropic Features to Direct Myoblast Orientation.Tissue engineering. Part C, Methods · 2024Article
- Low-cost, versatile, and highly reproducible microfabrication pipeline to generate 3D-printed customised cell culture devices with complex designs.PLoS biology · 2024Article
- Cellular Senescence Program is Sensitive to Physical Differences in Polymeric Tissue Scaffolds.ACS materials Au · 2024Article
- Recent progress in carbon dots for anti-pathogen applications in oral cavity.Frontiers in cellular and infection microbiology · 2023Review
- A Beginner's Guide to the Characterization of Hydrogel Microarchitecture for Cellular Applications.Gels (Basel, Switzerland) · 2022Review
- Topography-Mediated Enhancement of Nonviral Gene Delivery in Stem Cells.Pharmaceutics · 2022Article
- Synergistic stimulation of surface topography and biphasic electric current promotes muscle regeneration.Bioactive materials · 2022Article
- The Development of Biomimetic Aligned Skeletal Muscles in a Fully 3D Printed Microfluidic Device.Biomimetics (Basel, Switzerland) · 2021Article
- Nano-sized graphene oxide coated nanopillars on microgroove polymer arrays that enhance skeletal muscle cell differentiation.Nano convergence · 2021Article
- Cardiomyogenic Differentiation Potential of Human Dilated Myocardium-Derived Mesenchymal Stem/Stromal Cells: The Impact of HDAC Inhibitor SAHA and Biomimetic Matrices.International journal of molecular sciences · 2021Article
- Anisometric Microstructures to Determine Minimal Critical Physical Cues Required for Neurite Alignment.Advanced healthcare materials · 2021Article
- High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology.Chemical reviews · 2021Review
- Next Stage Approach to Tissue Engineering Skeletal Muscle.Bioengineering (Basel, Switzerland) · 2020Review
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- Directional topography gradients drive optimum alignment and differentiation of human myoblasts.Journal of tissue engineering and regenerative medicine · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue engineering of skeletal muscle aims to replicate the parallel alignment of myotubes on the native tissue. Directional topography gradients allow the study of the influence of topography on cellular orientation, proliferation, and differentiation, resulting in yield cues and clues to develop a proper in vitro environment for muscle tissue engineering. In this study, we used a polydimethylsiloxane-based substrate containing an aligned topography gradient with sinusoidal features ranging from wavelength (λ) = 1,520 nm and amplitude (A) =176 nm to λ = 9,934 nm and A = 2,168 nm. With this topography gradient, we evaluated the effect of topography on human myoblasts distribution, dominant orientation, cell area, nuclei coverage, cell area per number of nuclei, and nuclei area of myotubes. We showed that human myoblasts aligned and differentiated irrespective of the topography section. In addition, aligned human myotubes showed functionality and maturity by contracting spontaneously and nuclei peripheral organization resembling natural myotubes.
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