Evidence map›Paper›PMID 31677133›Full record

ReviewHuman genetics2020

Widespread sex dimorphism in aging and age-related diseases.

Nirmal K Sampathkumar, Juan I Bravo, Yilin Chen, Prakroothi S Danthi, Erin K Donahue, Rochelle W Lai, Ryan Lu, Lewis T Randall, Nika Vinson, Bérénice A Benayoun

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Human genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  12. A multi-omics analysis of human fibroblasts overexpressing anbioRxiv : the preprint server for biology · 2025
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  17. Ndufs4GeroScience · 2025
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nirmal K SampathkumarLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Juan I BravoLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Yilin ChenLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Prakroothi S DanthiLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Erin K DonahueLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Rochelle W LaiLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Ryan LuLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Lewis T RandallLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Nika VinsonDepartment of Urology, Pelvic Medicine and Reconstructive Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA, 90024, USA.
Bérénice A BenayounLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA. berenice.benayoun@usc.edu.ORCID http://orcid.org/0000-0002-7401-4777

Funding

USC Geroscience Training in the Biology of AgingT32AG052374 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sean P CURRAN · 2016 to 2026
$5.3M
Regulation of transcriptional consistency by broad H3K4me3 domains in young cells and during agingR00AG049934 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BENAYOUN, BERENICE ANATH · 2017 to 2019
$717k
Transposable elements as drivers of normal and accelerated aging in VertebratesR21AG063739 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BENAYOUN, BERENICE ANATH · 2019 to 2020
$464k
National Science Foundation DGE-1842487NIA NIH HHS R00 AG049934NIA NIH HHS R00AG049934NIA NIH HHS R21 AG063739NIA NIH HHS R21AG063739NIA NIH HHS T32 AG052374NIA NIH HHS T32AG052374
6 · The paper itself

Abstract

Although aging is a conserved phenomenon across evolutionary distant species, aspects of the aging process have been found to differ between males and females of the same species. Indeed, observations across mammalian studies have revealed the existence of longevity and health disparities between sexes, including in humans (i.e. with a female or male advantage). However, the underlying mechanisms for these sex differences in health and lifespan remain poorly understood, and it is unclear which aspects of this dimorphism stem from hormonal differences (i.e. predominance of estrogens vs. androgens) or from karyotypic differences (i.e. XX vs. XY sex chromosome complement). In this review, we discuss the state of the knowledge in terms of sex dimorphism in various aspects of aging and in human age-related diseases. Where the interplay between sex differences and age-related differences has not been explored fully, we present the state of the field to highlight important future research directions. We also discuss various dietary, drug or genetic interventions that were shown to improve longevity in a sex-dimorphic fashion. Finally, emerging tools and models that can be leveraged to decipher the mechanisms underlying sex differences in aging are also briefly discussed.

Indexed as

AgingAnimalsHumansLongevitySex Characteristics

Identifiers

PMID31677133
PMCPMC7031050

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.