Evidence map›Paper›PMID 31677067›Full record

Trial reportJournal of neurovirology2020

Cognitive impairment and CSF proteome modification after oral bacteriotherapy in HIV patients.

Claudia Landi, Letizia Santinelli, Laura Bianchi, Enxhi Shaba, Giancarlo Ceccarelli, Eugenio Nelson Cavallari, Cristian Borrazzo, Claudia Pinacchio, Carolina Scagnolari, Vincenzo Vullo and 2 more

Open access · greenAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Journal of neurovirology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Claudia LandiLaboratory Functional Proteomics, Department Life Sciences, University of Siena, Siena, Italy.
Letizia SantinelliDepartment of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Rome, Italy.
Laura BianchiLaboratory Functional Proteomics, Department Life Sciences, University of Siena, Siena, Italy.
Enxhi ShabaLaboratory Functional Proteomics, Department Life Sciences, University of Siena, Siena, Italy.
Giancarlo CeccarelliDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy. giancarlo.ceccarelli@uniroma1.it.ORCID 0000-0001-5921-3180
Eugenio Nelson CavallariDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Cristian BorrazzoDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Claudia PinacchioDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Carolina ScagnolariDepartment of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Rome, Italy.
Vincenzo VulloDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Luca BiniLaboratory Functional Proteomics, Department Life Sciences, University of Siena, Siena, Italy.
Gabriella d'EttorreDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Policlinico Umberto I · ITUniversity of Siena · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate whether a probiotic supplementation to cART patients modifies the cerebrospinal fluid (CSF) proteome and improves neurocognitive impairment.

methods26 CSF samples from 13 HIV-positive patients [six patients living with HIV (PLHIV) and seven patients with a history of AIDS (PHAIDS)] were analyzed. All patients underwent to neurocognitive evaluation and blood sampling at baseline and after 6 months of oral bacteriotherapy. Immune phenotyping and activation markers (CD38 and HLA-DR) were evaluated on peripheral blood mononuclear cells (PBMC). Plasma levels of IL-6, sCD14, and MIP-1β were detected, by enzyme-linked immunosorbent assay (ELISA). Functional proteomic analysis of CSF sample was conducted by two-dimensional electrophoresis; a multivariate analysis was performed by principal component analysis (PCA) and data were enriched by STRING software.

resultsOral bacteriotherapy leads to an improvement on several cognitive test and neurocognitive performance in both groups of HIV-positive subjects. A reduction in the percentage of CD4

conclusionsOur results suggest that oral bacteriotherapy as a supplement to cART could exert a role in the amelioration of inflammation state at peripheral and CNS level.

Indexed as

Acquired Immunodeficiency SyndromeAdultAIDS Dementia ComplexAnti-HIV AgentsCerebrospinal FluidCognitive DysfunctionFemaleHIV InfectionsHumansMaleMicrobiotaMiddle AgedMouthProbioticsProteomeAnti-HIV AgentsProteomeBacteriotherapyFunctional proteomicsHIVImmunoactivationProbiotic

Identifiers

PMID31677067
OpenAlexW2985321611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.