Evidence map›Paper›PMID 31677059›Full record

ReviewTransgenic research2020

CRISPR-associated nucleases: the Dawn of a new age of efficient crop improvement.

Rishikesh Ghogare, Bruce Williamson-Benavides, Fabiola Ramírez-Torres, Amit Dhingra

Open access · greenAbstract readReview
In one paragraph

Review in Transgenic research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

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  16. Identification ofFrontiers in genetics · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rishikesh GhogareWashington State University, Pullman, USA.
Bruce Williamson-BenavidesWashington State University, Pullman, USA.
Fabiola Ramírez-TorresWashington State University, Pullman, USA.
Amit DhingraWashington State University, Pullman, USA. adhingra@wsu.edu.ORCID 0000-0002-4464-2502
Washington State University · US

Funding

National Institute of Food and Agriculture WPN00011
6 · The paper itself

Abstract

The world stands at a new threshold today. As a planet, we face various challenges, and the key one is how to continue to produce enough food, feed, fiber, and fuel to support the burgeoning population. In the past, plant breeding and the ability to genetically engineer crops contributed to increasing food production. However, both approaches rely on random mixing or integration of genes, and the process can be unpredictable and time-consuming. Given the challenge of limited availability of natural resources and changing environmental conditions, the need to rapidly and precisely improve crops has become urgent. The discovery of CRISPR-associated endonucleases offers a precise yet versatile platform for rapid crop improvement. This review summarizes a brief history of the discovery of CRISPR-associated nucleases and their application in genome editing of various plant species. Also provided is an overview of several new endonucleases reported recently, which can be utilized for editing of specific genes in plants through various forms of DNA sequence alteration. Genome editing, with its ever-expanding toolset, increased efficiency, and its potential integration with the emerging synthetic biology approaches hold promise for efficient crop improvement to meet the challenge of supporting the needs of future generations.

Indexed as

CRISPR-Cas SystemsGene EditingGenome, PlantCrops, AgriculturalEndonucleasesGenetic EngineeringPlants, Genetically ModifiedEndonucleasesCas endonucleasesCRISPRCrop improvementGene editingPlants

Identifiers

PMID31677059
PMCPMC7578434
OpenAlexW2985332575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.