Evidence map›Paper›PMID 31676990›Full record

SynthesisMagma (New York, N.Y.)2020

Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI.

Alexandra Ljimani, Anna Caroli, Christoffer Laustsen, Susan Francis, Iosif Alexandru Mendichovszky, Octavia Bane, Fabio Nery, Kanishka Sharma, Andreas Pohlmann, Ilona A Dekkers and 16 more

Erratum issuedAbstract readConsensus StatementSystematic Review
In one paragraph

Synthesis in Magma (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed.

  1. Diffusion MRI of the Body: Beyond PGSE-EPI.Journal of magnetic resonance imaging : JMRI · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Multiparametric MR Imaging for Evaluating Renal Function and Microstructure.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Alexandra LjimaniDepartment of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany. alexandra.ljimani@med.uni-duesseldorf.de.ORCID http://orcid.org/0000-0002-9748-9927
Anna CaroliDepartment of Biomedical Engineering, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.ORCID http://orcid.org/0000-0002-4130-4663
Christoffer LaustsenMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Susan FrancisSir Peter Mansfield Imaging Centre, University Park, University of Nottingham, Nottingham, NG7 2RD, UK.
Iosif Alexandru MendichovszkyDepartment of Radiology, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, UK.
Octavia BaneTranslational and Molecular Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Fabio NeryDevelopmental Imaging and Biophysics Section, UCL Great Ormond Street Institute of Child Health, London, UK.
Kanishka SharmaImaging Biomarkers Group, Department of Biomedical Imaging Sciences, University of Leeds, Leeds, UK.
Andreas PohlmannBerlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, 13125, Berlin, Germany.
Ilona A DekkersDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Jean-Paul ValleeDepartment of Diagnostic, Geneva University Hospital and University of Geneva, 1211, Geneva-14, Switzerland.
Katja DerlinDepartment of Radiology, Hannover Medical School, Hannover, Germany.
Mike NotohamiprodjoDie Radiologie, Munich, Germany.
Ruth P LimDepartment of Radiology, Austin Health, The University of Melbourne, Melbourne, Australia.
Stefano PalmucciDepartment of Medical Surgical Sciences and Advanced Technologies, Radiology I Unit, University Hospital "Policlinico-Vittorio Emanuele", University of Catania, Catania, Italy.
Suraj D SeraiDepartment of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Joao PeriquitoBerlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, 13125, Berlin, Germany.
Zhen Jane WangDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Martijn FroelingDepartment of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-3841-0497
Harriet C ThoenyDepartment of Radiology, Hôpital Cantonal Fribourgois (HFR), University of Fribourg, 1708, Fribourg, Switzerland.
Pottumarthi PrasadDepartment of Radiology, Center for Advanced Imaging, NorthShore University Health System, Evanston, IL, USA.
Moritz SchneiderDepartment of Radiology, University Hospital, LMU Munich, Munich, Germany.
Thoralf NiendorfBerlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, 13125, Berlin, Germany.
Pim PullensGhent Institute for Functional and Metabolic Imaging, Ghent University, Ghent, Belgium.
Steven SourbronImaging Biomarkers Group, Department of Biomedical Imaging Sciences, University of Leeds, Leeds, UK.
Eric E SigmundDepartment of Radiology, Center for Biomedical Imaging (CBI), Center for Advanced Imaging Innovation and Research (CAI2R), NYU Langone Health, New York, NY, USA.

Funding

Quantification of Renal Perfusion, Diffusion and Hypoxia Using Advanced MRI Methods for Assessment of Renal Transplant DysfunctionF32DK109591 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BANE, OCTAVIA · 2016 to 2018
$126k
Bundesministerium für Forschung und Technologie VIP 03P00081Deutsche Forschungsgemeinschaft SFB 1365European Cooperation in Science and Technology CA16103H2020 European Research Council 115974Medical Research Council MR/R02264X/1Medical Research Council UK MR/R02264X/1NIDDK NIH HHS 1F32DK109591NIDDK NIH HHS F32 DK109591Swiss Re Foundation IZCOZ0_177140/1
6 · The paper itself

Abstract

objectivesStandardization is an important milestone in the validation of DWI-based parameters as imaging biomarkers for renal disease. Here, we propose technical recommendations on three variants of renal DWI, monoexponential DWI, IVIM and DTI, as well as associated MRI biomarkers (ADC, D, D*, f, FA and MD) to aid ongoing international efforts on methodological harmonization. MATERIALS AND

methodsReported DWI biomarkers from 194 prior renal DWI studies were extracted and Pearson correlations between diffusion biomarkers and protocol parameters were computed. Based on the literature review, surveys were designed for the consensus building. Survey data were collected via Delphi consensus process on renal DWI preparation, acquisition, analysis, and reporting. Consensus was defined as ≥ 75% agreement.

resultsCorrelations were observed between reported diffusion biomarkers and protocol parameters. Out of 87 survey questions, 57 achieved consensus resolution, while many of the remaining questions were resolved by preference (65-74% agreement). Summary of the literature and survey data as well as recommendations for the preparation, acquisition, processing and reporting of renal DWI were provided. DISCUSSION: The consensus-based technical recommendations for renal DWI aim to facilitate inter-site harmonization and increase clinical impact of the technique on a larger scale by setting a framework for acquisition protocols for future renal DWI studies. We anticipate an iterative process with continuous updating of the recommendations according to progress in the field.

Indexed as

BiomarkersDiffusion Magnetic Resonance ImagingKidneyTranslational Research, BiomedicalAlgorithmsDelphi TechniqueHumansImage Interpretation, Computer-AssistedModels, StatisticalMotionReproducibility of ResultsSurveys and QuestionnairesBiomarkersADCBiomarkerDTIDWIIVIM

Identifiers

PMID31676990
PMCPMC7021760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.