ArticleNature genetics2019
Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease.
Open access · greenAbstract read
In one paragraph
Article in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 4 pooled it
19.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
147 citing papers in PubMed, 4 syntheses or guidelines pooled it, 247 citations in OpenAlex.
- GP6 polymorphisms and venous thromboembolism: a Chinese case-control study with cross-population assessment.BMC cardiovascular disorders · 2026Pooled it
- Genome-wide association analyses identified novel susceptibility loci for pulmonary embolism among Han Chinese population.BMC medicine · 2023Pooled it
- Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism.Nature genetics · 2023Pooled it
- The Effect of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibition on the Risk of Venous Thromboembolism.Circulation · 2020Pooled it
- In vivo and ex vivo impact of THBD and PROCR polymorphisms on the anticoagulant response of the protein C pathway.Blood advances · 2026Article
- Abnormal lipid profiles are associated with markers of impaired fibrinolysis in patients with cirrhosis.Research and practice in thrombosis and haemostasis · 2026Observational
- Genetic Evidence That Stroke Causally Increases Circulating PDGFB Levels: a Two-Sample Mendelian Randomization Study.Journal of molecular neuroscience : MN · 2026Article
- Disproportionate Risk of Cancer Following Diagnosis of Peripheral Artery Disease.JACC. Advances · 2026Article
- Real-world data on Factor V Leiden in Sweden: A nationwide family study.Journal of thrombosis and thrombolysis · 2026Article
- Tumor Whole-Genome Sequencing for Prediction of Venous Thromboembolism in Patients With Metastasized Solid Cancer.Circulation. Genomic and precision medicine · 2026Article
- A sensitized model of thrombosis validates known multigenic relationships and suggests novel modifiers of hemostasis.bioRxiv : the preprint server for biology · 2026Article
- Admixture-informed polygenic risk reporting using the ePRS framework.Nature communications · 2026Article
- Population-scale analysis reveals inherited C1-inhibitor deficiency is a polyphenotypic thrombotic disorder.Blood advances · 2026Article
- Genetic risk assessment of pregnancy-associated venous thromboembolism: dual utility of maternal peripheral blood in NIPT and VTE evaluation.BMC pregnancy and childbirth · 2026Article
- Integration of hereditary thrombophilia data and polygenic risk scores into prognostic models improves differential diagnosis of CTEPH.Frontiers in cardiovascular medicine · 2026Article
- Variant-to-Biomarker Pathways in Peripheral Artery Disease: Multiomics Integration and Clinical Translation.Human mutation · 2026Review
- Multi-Omics Prioritization and Clinical Evaluation of CYP4V2 as a Candidate Biomarker in Venous Thromboembolism.International journal of general medicine · 2026Article
- Human genetics implicate thromboembolism in the pathogenesis of long COVID in individuals of European ancestry.Nature cardiovascular research · 2025Article
- Multipopulation GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish.Blood advances · 2025Article
- Genetic Risk Profiles for Atherosclerosis and Venous Thromboembolism in Azorean and Mainland Portuguese Populations: A Comparative Analysis.Current issues in molecular biology · 2025Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
44 authors at 19 institutions in 2 countries.
Derek KlarinVeterans Affairs Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4636-5780
Emma BusenkellCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Renae JudyCorporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.
Julie LynchVeterans Affairs Informatics and Computing Infrastructure, Veterans Affairs Salt Lake City Health Care System, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0003-0108-2127
Michael LevinCorporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9937-9932
Jeffery HaesslerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Krishna AragamCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Mark ChaffinProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1234-5562
Mary HaasProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Sara LindströmDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Themistocles L AssimesVeterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0003-2349-0009
Jie HuangMassachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, MA, USA.
Kyung Min LeeVeterans Affairs Informatics and Computing Infrastructure, Veterans Affairs Salt Lake City Health Care System, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0001-8995-0448
Qing ShaoCenter for Healthcare Organization and Implementation Research, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, USA.
Jennifer E HuffmanMassachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9672-2491
Christopher KabrhelCenter for Vascular Emergencies, Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA.
Yunfeng HuangDepartment of Epidemiology, Emory University Rollins School of Public Health, Department of Biomedical Informatics Emory University School of Medicine, Atlanta, GA, USA.
Yan V SunDepartment of Epidemiology, Emory University Rollins School of Public Health, Department of Biomedical Informatics Emory University School of Medicine, Atlanta, GA, USA.
Marijana VujkovicCorporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-4924-5714
Danish SaleheenCorporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.
Donald R MillerCenter for Healthcare Organization and Implementation Research, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, USA.
Peter ReavenPhoenix Veterans Affairs Health Care System, Phoenix, AZ, USA.
Scott DuVallVeterans Affairs Informatics and Computing Infrastructure, Veterans Affairs Salt Lake City Health Care System, Salt Lake City, UT, USA.
William E BodenMassachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, MA, USA.
Saiju PyarajanMassachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, MA, USA.
Alex P ReinerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
David-Alexandre TrégouëtBordeaux Population Health Research Center (INSERM UMR S 1219), University of Bordeaux, Bordeaux, France.
Peter HenkeSection of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
J Michael GazianoMassachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, MA, USA.
John ConcatoClinical Epidemiology Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.
Daniel J RaderDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kelly ChoMassachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, MA, USA.
Kyong-Mi ChangCorporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.
Peter W F WilsonAtlanta Veterans Affairs Health Care System, Decatur, GA, USA.
Nicholas L SmithDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Christopher J O'DonnellVeterans Affairs Boston Healthcare System, Boston, MA, USA.
Philip S TsaoVeterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0001-7274-9318
Sekar KathiresanCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6724-032X
Andrea ObiSection of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
Scott M Damrauer *Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8009-1632
Pradeep Natarajan *Veterans Affairs Boston Healthcare System, Boston, MA, USA. pnatarajan@mgh.harvard.edu.ORCID http://orcid.org/0000-0001-8402-7435
INVENT Consortium
Veterans Affairs’ Million Veteran Program
Broad Institute · USBrigham and Women's Hospital · USVA Boston Healthcare System · USBoston University · USEmory University · USHarvard University · USPhiladelphia VA Medical Center · USUniversité de Bordeaux · FRUniversity of Massachusetts Boston · USUniversity of Michigan · USVA Palo Alto Health Care System · USEdith Nourse Rogers Memorial Veterans Hospital · USEmory Healthcare · USFred Hutch Cancer Center · USKaiser Permanente Washington Health Research Institute · USUniversity of Utah · USUniversity of Washington · USVA Salt Lake City Healthcare System · USYale University · US
Funding
Using genetic variation to study biology of blood lipids & coronary heart diseaseR01HL127564 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pradeep Natarajan, Gina Marie Peloso · 2015 to 2026
$7.3MClonal hematopoiesis in humans: determinants of development and progressionR01HL148050 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE MITCHELL, NATARAJAN, PRADEEP · 2019 to 2022
$5.9MWhole genome sequences in individuals to comprehensively characterize the genetic mechanisms of dyslipidemiasR01HL142711 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Satoshi Koyama, Gina Marie Peloso · 2019 to 2026
$4.7MGenetic and Environmental Risk Factors for Venous ThromboembolismR01HL116854 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KABRHEL, CHRISTOPHER · 2013 to 2017
$3.4MPopulation genomic variation, functional biology, and the risk of venous thrombosisR01HL134894 · NHLBI · UNIVERSITY OF WASHINGTON · PI LOWENSTEIN, CHARLES J, SMITH, NICHOLAS L · 2017 to 2020
$2.9MFHCRC High-Performance Computing ClusterS10OD020069 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L · 2015 to 2015
$600kUnderstanding modifiers of mendelian mutation penetrance using familial hypercholesterolemia as a modelK08HL140203 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NATARAJAN, PRADEEP · 2018 to 2019
$343kPrecision Cardio-Metabolic Phenotyping for Genetic Discovery and Risk PredictionIK2CX001780 · VA · PHILADELPHIA VA MEDICAL CENTER · PI DAMRAUER, SCOTT MICHAEL · 2018 to 2023
–Prediction of CVD Risk in VeteransI01CX001025 · VA · VETERANS HEALTH ADMINISTRATION · PI CHO, KELLY, WILSON, PETER WYMAN · 2014 to 2025
–Genetics of Cardiometabolic Diseases in the VA PopulationI01BX003362 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI Kyong-Mi Chang, Philip S Tsao · 2017 to 2026
–Cardiovascular Disease Risk Factors, Prevalent Cardiovascular Disease, and Genetics in the Million Veteran ProgramI01BX003340 · VA · VETERANS HEALTH ADMINISTRATION · PI CHO, KELLY, WILSON, PETER WYMAN · 2017 to 2017
–BLRD VA I01 BX003340BLRD VA I01 BX003362CSRD VA I01 CX001025CSRD VA IK2 CX001780Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS K08 HL140203NHLBI NIH HHS R01 HL116854NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R01 HL134894NHLBI NIH HHS R01 HL142711NHLBI NIH HHS R01 HL148050NIH HHS S10 OD020069
Abstract
Venous thromboembolism is a significant cause of mortality
Indexed as
Genetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyAgedAnimalsCase-Control StudiesFemaleHumansMaleMiceMice, Inbred C57BLMiddle AgedPlasminogen Activator Inhibitor 1Risk FactorsUnited KingdomVascular DiseasesPlasminogen Activator Inhibitor 1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.