ArticleScientific reports2019
Proteomic changes in the milk of water buffaloes (Bubalus bubalis) with subclinical mastitis due to intramammary infection by Staphylococcus aureus and by non-aureus staphylococci.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Genotypic detection of some virulence factors and genetic tree ofOpen veterinary journal · 2026Article
- Comprehensive evaluation of milk biomarkers as indicators of intramammary infection in dairy goats across lactation.Scientific reports · 2026Article
- Identification of MAPK10 as a Candidate Gene for High Milk Production in Water Buffaloes Through a Genome-Wide Association Study.Animals : an open access journal from MDPI · 2025Article
- Article
- Buffalo Immune Competence Under Infectious and Non-Infectious Stressors.Animals : an open access journal from MDPI · 2025Review
- Impact of a teat disinfectant based on Lactococcus cremoris on the cow milk proteome.BMC veterinary research · 2024Article
- Association between somatic cell count or morbidity of chronic subclinical mastitis and longevity in dairy herds in Eastern Hokkaido, Japan: a cross-sectional study.The Journal of veterinary medical science · 2024Article
- Article
- Comprehensive proteomic analysis reveals omega-3 fatty acids to counteract endotoxin-stimulated metabolic dysregulation in porcine enterocytes.Scientific reports · 2023Article
- Molecular characteristics ofFrontiers in veterinary science · 2023Article
- Toll-like Receptor 2 Is Associated with the Immune Response, Apoptosis, and Angiogenesis in the Mammary Glands of Dairy Cows with Clinical Mastitis.International journal of molecular sciences · 2022Article
- Review
- Changes in the lipidome of water buffalo milk during intramammary infection by non-aureus Staphylococci.Scientific reports · 2022Article
- Peptidomic changes in the milk of water buffaloes (Bubalus bubalis) with intramammary infection by non-aureus staphylococci.Scientific reports · 2022Article
- Exposure of Buffalo Milkers to Pathogenic Bacteria and Characterization of Isolated Methicillin-ResistantInternational journal of environmental research and public health · 2022Article
- Exploring the DPP-IV Inhibitory, Antioxidant and Antibacterial Potential of Ovine "Scotta" Hydrolysates.Foods (Basel, Switzerland) · 2021Article
- Dynamics of Macrophages and Polymorphonuclear Leukocytes Milk-Secreted by Buffaloes with Udders Characterized by Different Clinical Status.Veterinary sciences · 2021Article
- Integrative Analysis of miRNA and mRNA Expression Profiles in Mammary Glands of Holstein Cows Artificially Infected withPathogens (Basel, Switzerland) · 2021Article
- Proteomic 2D-DIGE Analysis of Milk Whey from Dairy Cows withMicroorganisms · 2020Article
- Antibiotic dry buffalo therapy: effect of intramammary administration of benzathine cloxacillin against Staphylococcus aureus mastitis in dairy water buffalo.BMC veterinary research · 2020Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subclinical mastitis by Staphylococcus aureus (SAU) and by non-aureus staphylococci (NAS) is a major issue in the water buffalo. To understand its impact on milk, 6 quarter samples with >3,000,000 cells/mL (3 SAU-positive and 3 NAS-positive) and 6 culture-negative quarter samples with <50,000 cells/mL were investigated by shotgun proteomics and label-free quantitation. A total of 1530 proteins were identified, of which 152 were significantly changed. SAU was more impacting, with 162 vs 127 differential proteins and higher abundance changes (P < 0.0005). The 119 increased proteins had mostly structural (n = 43, 28.29%) or innate immune defence functions (n = 39, 25.66%) and included vimentin, cathelicidins, histones, S100 and neutrophil granule proteins, haptoglobin, and lysozyme. The 33 decreased proteins were mainly involved in lipid metabolism (n = 13, 59.10%) and included butyrophilin, xanthine dehydrogenase/oxidase, and lipid biosynthetic enzymes. The same biological processes were significantly affected also upon STRING analysis. Cathelicidins were the most increased family, as confirmed by western immunoblotting, with a stronger reactivity in SAU mastitis. S100A8 and haptoglobin were also validated by western immunoblotting. In conclusion, we generated a detailed buffalo milk protein dataset and defined the changes occurring in SAU and NAS mastitis, with potential for improving detection (ProteomeXchange identifier PXD012355).
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