ArticleScientific reports2019
Developmental conditions modulate DNA methylation at the glucocorticoid receptor gene with cascading effects on expression and corticosterone levels in zebra finches.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Beyond the Chicken: Alternative Avian Models for Developmental Physiological Research.Frontiers in physiology · 2021Pooled it
- Lasting benefits of embryonic eavesdropping on parent-parent communication.Science advances · 2024Article
- Exploring Maternal Diet-Epigenetic-Gut Microbiome Crosstalk as an Intervention Strategy to Counter Early Obesity Programming.Current issues in molecular biology · 2024Review
- Modelling the role of glucocorticoid receptor as mediator of endocrine responses to environmental challenge.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- HPA flexibility andPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Early developmental carry-over effects on exploratory behaviour and DNA methylation in wild great tits (Evolutionary applications · 2024Article
- From maternal glucocorticoid and thyroid hormones to epigenetic regulation of offspring gene expression: An experimental study in a wild bird species.Evolutionary applications · 2023Article
- Effects of manipulated food availability and seasonality on innate immune function in a passerine.The Journal of animal ecology · 2022Article
- Great tits differ in glucocorticoid plasticity in response to spring temperature.Proceedings. Biological sciences · 2022Article
- Effects of early-life conditions on innate immune function in adult zebra finches.The Journal of experimental biology · 2021Article
- Glucocorticoid Signaling and Epigenetic Alterations in Stress-Related Disorders.International journal of molecular sciences · 2021Review
- Urbanization is associated with modifications in DNA methylation in a small passerine bird.Evolutionary applications · 2021Article
- Article
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4 authors.
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Abstract
Developmental conditions can impact the adult phenotype via epigenetic changes that modulate gene expression. In mammals, methylation of the glucocorticoid receptor gene Nr3c1 has been implicated as mediator of long-term effects of developmental conditions, but this evidence is limited to humans and rodents, and few studies have simultaneously tested for associations between DNA methylation, gene expression and phenotype. Adverse environmental conditions during early life (large natal brood size) or adulthood (high foraging costs) exert multiple long-term phenotypic effects in zebra finches, and we here test for effects of these manipulations on DNA methylation and expression of the Nr3c1 gene in blood. Having been reared in a large brood induced higher DNA methylation of the Nr3c1 regulatory region in adulthood, and this effect persisted over years. Nr3c1 expression was negatively correlated with methylation at 2 out of 8 CpG sites, and was lower in hard foraging conditions, despite foraging conditions having no effect on Nr3c1 methylation at our target region. Nr3c1 expression also correlated with glucocorticoid traits: higher expression level was associated with lower plasma baseline corticosterone concentrations and enhanced corticosterone reactivity. Our results suggest that methylation of the Nr3c1 regulatory region can contribute to the mechanisms underlying the emergence of long-term effects of developmental conditions in birds, but in our system current adversity dominated over early life experiences with respect to receptor expression.
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