Evidence map›Paper›PMID 31676770›Full record

ArticleNature communications2019

CXCR3 enables recruitment and site-specific bystander activation of memory CD8

Nicholas J Maurice, M Juliana McElrath, Erica Andersen-Nissen, Nicole Frahm, Martin Prlic

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 109 citations in OpenAlex.

  1. Article
  2. B cell-intrinsic CXCR3 drives efficient generation of ectopic pulmonary germinal center responses to influenza A virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
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  7. Article
  8. CXCL10 Regulates Pressure Overload-Induced Heart Failure.JACC. Basic to translational science · 2026
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
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  17. Article
  18. Review
  19. Article
  20. CXCL12/CXCR4 axis mediates CD8Journal of translational medicine · 2025
    Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Nicholas J MauriceVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0002-2667-472X
M Juliana McElrathVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Erica Andersen-NissenVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Nicole FrahmVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0003-1298-3676
Martin PrlicVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA. mprlic@fredhutch.org.ORCID http://orcid.org/0000-0002-0685-9321
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZADesmond Tutu HIV Foundation · ZAFred Hutch Cancer Center · USUniversity of Washington · US

Funding

NRSA Training CoreTL1TR002318 · NCATS · UNIVERSITY OF WASHINGTON · PI Megan Moore · 2017 to 2026
$8.4M
Inflammation-driven T Cell Responses and their Dichotomous Effect on Host ImmunityR01AI123323 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PRLIC, MARTIN · 2017 to 2025
$5.0M
NCATS NIH HHS TL1 TR002318NIAID NIH HHS R01 AI123323
6 · The paper itself

Abstract

Bystander activation of memory T cells occurs in the absence of cognate antigen during infections that elicit strong systemic inflammatory responses, which subsequently affect host immune responses. Here we report that memory T cell bystander activation is not limited to induction by systemic inflammation. We initially observe potential T cell bystander activation in a cohort of human vaccine recipients. Using a mouse model system, we then find that memory CD8

Indexed as

AnimalsAntigen-Presenting CellsAntigensBystander EffectCD8-Positive T-LymphocytesFemaleHumansImmunizationImmunologic MemoryInflammationLymphocyte ActivationMice, Inbred C57BLMice, KnockoutReceptors, CXCR3AntigensCxcr3 protein, mouseReceptors, CXCR3

Identifiers

PMID31676770
PMCPMC6825240
OpenAlexW2988372882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.