Evidence map›Paper›PMID 31676759›Full record

ArticleNature communications2019

Infant airway microbiota and topical immune perturbations in the origins of childhood asthma.

Jonathan Thorsen, Morten A Rasmussen, Johannes Waage, Martin Mortensen, Asker Brejnrod, Klaus Bønnelykke, Bo L Chawes, Susanne Brix, Søren J Sørensen, Jakob Stokholm and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05063149 (Protecting Late-moderate Preterm Infants From Respiratory Tract Infections and Wheeze in Their First Years of Life by Using Bacterial Lysates.), which is not on this map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
24.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05063149 phase3recruitingnot on this mapstarted 2022, after this paper: background citation

Protecting Late-moderate Preterm Infants From Respiratory Tract Infections and Wheeze in Their First Years of Life by Using Bacterial Lysates.

TypeinterventionalSponsorFranciscus GasthuisRan2022 to 2026Enrolled500ConditionsWheezing, LRTI, PrematureArmsBroncho-Vaxom, Placebo
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 157 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Microbial influencers: the airway microbiome's role in asthma.The Journal of clinical investigation · 2025
    Review
  19. The neonate respiratory microbiome.Acta physiologica (Oxford, England) · 2025
    Review
  20. Clinical relevance of lung microbiota composition in critically ill children with acute lower respiratory tract infections: insights from a retrospective analysis of metagenomic sequencing.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jonathan ThorsenCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-0200-0461
Morten A RasmussenCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-7431-5206
Johannes WaageCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Martin MortensenSection of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5483-7533
Asker BrejnrodSection of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-1327-2051
Klaus BønnelykkeCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2003-1018
Bo L ChawesCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6846-6243
Susanne BrixDisease Systems Immunology, Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark.ORCID http://orcid.org/0000-0001-8951-6705
Søren J SørensenSection of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6227-9906
Jakob StokholmCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4989-9769
Hans BisgaardCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. bisgaard@copsac.com.ORCID http://orcid.org/0000-0003-4131-7592
University of Copenhagen · DKTechnical University of Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asthma is believed to arise through early life aberrant immune development in response to environmental exposures that may influence the airway microbiota. Here, we examine the airway microbiota during the first three months of life by 16S rRNA gene amplicon sequencing in the population-based Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC

Indexed as

AsthmaBacteriaChildCytokinesFemaleHumansInfantInfant, NewbornMaleMicrobiotaPrevotellaProspective StudiesRespiratory SystemRNA, Ribosomal, 16SVeillonellaCytokinesRNA, Ribosomal, 16S

Identifiers

PMID31676759
PMCPMC6825176
OpenAlexW2987143686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.