Evidence map›Paper›PMID 31676688›Full record

ArticleThe Journal of biological chemistry2019

Residues and residue pairs of evolutionary importance differentially direct signaling bias of D2 dopamine receptors.

María E Terrón-Díaz, Sara J Wright, Melina A Agosto, Olivier Lichtarge, Theodore G Wensel

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

María E Terrón-DíazDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030.
Sara J WrightVerna and Marrs Mclean Department of Biochemistry and Molecular Biology Baylor College of Medicine, Houston, Texas 77030.
Melina A AgostoVerna and Marrs Mclean Department of Biochemistry and Molecular Biology Baylor College of Medicine, Houston, Texas 77030.ORCID 0000-0002-3647-1926
Olivier LichtargeDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030.
Theodore G WenselDepartment of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas 77030 twensel@bcm.edu.ORCID 0000-0003-3518-9352
Baylor College of Medicine · US

Funding

Functional Determinnats in G Protein-coupled ReceptorsR01GM066099 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI LICHTARGE, OLIVIER · 2003 to 2022
$7.5M
A Knowledge Map to Find Alzheimer's Disease DrugsR01AG061105 · NIA · BAYLOR COLLEGE OF MEDICINE · PI LICHTARGE, OLIVIER · 2018 to 2022
$4.6M
Cilium-Associated Structures in Rod CellsR01EY026545 · NEI · BAYLOR COLLEGE OF MEDICINE · PI WENSEL, THEODORE G · 2016 to 2024
$3.7M
Light regulation of retinal phosphoinositidesR01EY025218 · NEI · BAYLOR COLLEGE OF MEDICINE · PI WENSEL, THEODORE G · 2016 to 2019
$1.6M
NEI NIH HHS R01 EY007891NEI NIH HHS R01 EY025218NEI NIH HHS R01 EY026545NIA NIH HHS R01 AG061105NIGMS NIH HHS R01 GM066099
6 · The paper itself

Abstract

The D2 dopamine receptor and the serotonin 5-hydroxytryptamine 2A receptor (5-HT2A) are closely-related G-protein-coupled receptors (GPCRs) from the class A bioamine subfamily. Despite structural similarity, they respond to distinct ligands through distinct downstream pathways, whose dysregulation is linked to depression, bipolar disorder, addiction, and psychosis. They are important drug targets, and it is important to understand how their bias toward G-protein

Indexed as

Cells, CulturedDopamineDose-Response Relationship, DrugHEK293 CellsHumansReceptors, Dopamine D2SerotoninSignal TransductionDopamineDRD2 protein, humanReceptors, Dopamine D2Serotoninallosteric regulationarrestincell signalingdopaminedopamine receptorG proteinG-protein–coupled receptor (GPCR)

Identifiers

PMID31676688
PMCPMC6916503
OpenAlexW2982777282

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.