ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
The Salience Network: A Neural System for Perceiving and Responding to Homeostatic Demands.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 484 papers, 7 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
484 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Neural correlates of altered interoception in depressive and anxiety disorders: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- The many manifestations of magical thinking: a systematic review.Frontiers in psychiatry · 2026Pooled it
- A bias-accounting meta-analytic approach refines and expands the cerebellar behavioral topography.Neuroscience and biobehavioral reviews · 2025Pooled it
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- GINNA, a 33 resting-state networks atlas with meta-analytic decoding-based cognitive characterization.Communications biology · 2025Pooled it
- Evidence for domain-general arousal from semantic and neuroimaging meta-analyses reconciles opposing views on arousal.Proceedings of the National Academy of Sciences of the United States of America · 2025Pooled it
- The research progress on effective connectivity in adolescent depression based on resting-state fMRI.Frontiers in neurology · 2025Pooled it
- Ketamine's impact on rumination-related brain dynamics: insights from a randomized controlled fMRI trial.Translational psychiatry · 2026Trial
- Predicting treatment response to transcutaneous auricular vagus nerve stimulation in patients with insomnia: resting-state functional connectivity based multivoxel pattern analysis.BMC psychiatry · 2026Trial
- Functional architecture of the human insula.Nature · 2026Article
- Altered seed-to-whole-brain functional connectivity of goal-directed/habitual systems in obsessive-compulsive disorder: associated genes and preliminary classification potential.European archives of psychiatry and clinical neuroscience · 2026Article
- Article
- Treatment response to bupropion: an investigation of changes in resting-state functional connectivity in patients with major depressive disorder.Psychopharmacology · 2026Article
- Effects of opioids and stimulants on the respiratory system.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Aging, brain network connectivity, and cognition: evidence from resting-state dynamic arterial spin labeling.NeuroImage · 2026Article
- Why are you looking at me like that? Intolerance of uncertainty and emotional face processing in social anxiety disorder.NeuroImage. Clinical · 2026Article
- Is cold exposure a viable lifestyle intervention for mental health? Reviewing evidence and mechanisms.Molecular psychiatry · 2026Review
- Functional brain connectivity in clinical high-risk youth from the Kenya psychosis-risk outcomes study (KePROS): functional network comparative area and topography analysis (FUNCATA).NeuroImage. Clinical · 2026Article
- Salience Network Dynamics Across Spontaneous Attacks, Interictal Rest and Interictal Pain Imagery in Menstrually Related Migraine.Brain topography · 2026Article
- Exercise-induced neuropeptidergic and neurochemical neuroadaptation in stress regulation and emotional disorders.Acta neurologica Belgica · 2026Review
424 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The term "salience network" refers to a suite of brain regions whose cortical hubs are the anterior cingulate and ventral anterior insular (i.e., frontoinsular) cortices. This network, which also includes nodes in the amygdala, hypothalamus, ventral striatum, thalamus, and specific brainstem nuclei, coactivates in response to diverse experimental tasks and conditions, suggesting a domain-general function. In the 12 years since its initial description, the salience network has been extensively studied, using diverse methods, concepts, and mammalian species, including healthy and diseased humans across the lifespan. Despite this large and growing body of research, the essential functions of the salience network remain uncertain. In this paper, which makes no attempt to comprehensively review this literature, I describe the circumstances surrounding the initial discovery, conceptualization, and naming of the salience network, highlighting aspects that may be unfamiliar to many readers. I then discuss some of the key advances provided by subsequent research and conclude by posing a few of the questions that remain to be explored.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.