Evidence map›Paper›PMID 31676550›Full record

ArticleeNeuro

Functional Assessment

Qing Ouyang, Lena Joesch-Cohen, Sasmita Mishra, Hasib A Riaz, Michael Schmidt, Eric M Morrow

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Donor Splice Site Variant inMedicina (Kaunas, Lithuania) · 2022
    Article
  5. Review
  6. Loss of Christianson Syndrome NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Qing OuyangDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912.
Lena Joesch-CohenDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912.
Sasmita MishraDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912.
Hasib A RiazDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912.
Michael SchmidtDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912.
Eric M MorrowDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912 Eric_morrow@brown.edu.ORCID 0000-0003-3430-3520
Allen Institute for Brain Science · USJohn Brown University · US

Funding

Pathogenic Mechanisms in Christianson Syndrome and NHE6-Related DisordersR01NS113141 · NINDS · BROWN UNIVERSITY · PI Eric M Morrow · 2019 to 2026
$7.0M
Center for Cancer Signaling NetworksP30GM103410 · NIGMS · BROWN UNIVERSITY · PI ATWOOD, WALTER J · 2012 to 2015
$4.3M
Human 3D Microtissues for Toxicity Testing via Integrated Imaging, Molecular and Functional AnalysesU01ES028184 · NIEHS · BROWN UNIVERSITY · PI BOEKELHEIDE, KIM, MORGAN, JEFFREY R · 2017 to 2021
$3.8M
Mechanisms of circuit failure and treatments in patient-derived neurons in autismR01MH105442 · NIMH · BROWN UNIVERSITY · PI MORROW, ERIC M · 2014 to 2019
$2.8M
Autism-linked endosomal mechanisms in neuronal arborization and connectivityR01MH102418 · NIMH · BROWN UNIVERSITY · PI MORROW, ERIC M · 2015 to 2018
$1.6M
Convergent Cellular Mechanisms Governed by UBE3A and NHEs in NeuronsR21MH115392 · NIMH · BROWN UNIVERSITY · PI MORROW, ERIC M · 2017 to 2018
$447k
NIEHS NIH HHS U01 ES028184NIGMS NIH HHS P30 GM103410NIMH NIH HHS R01 MH102418NIMH NIH HHS R01 MH105442NIMH NIH HHS R21 MH115392NINDS NIH HHS R01 NS113141
6 · The paper itself

Abstract

Christianson syndrome (CS) is an X-linked neurogenetic disorder resulting from loss-of-function (LoF) mutations in

Indexed as

AnimalsFemaleGene EditingMaleMiceMice, KnockoutMutationNeuronsSodium-Hydrogen ExchangersNHE6 protein, mouseSLC9A6 protein, humanSodium-Hydrogen ExchangersChristianson syndromeendosomesgeneticsSLC9A6variant of unknown significance

Identifiers

PMID31676550
PMCPMC6893231
OpenAlexW2987281259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.