ArticleThe Journal of general physiology2019
Outer hair cell electromotility is low-pass filtered relative to the molecular conformational changes that produce nonlinear capacitance.
Article in The Journal of general physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Electromotility can be disassociated from gating charge movement in outer hair cells of conditional alpha2 spectrin knockout mice.The Journal of biological chemistry · 2026Article
- Chloride binding does not influence prestin motor speed at very high frequencies in the mouse outer hair cell.Structure (London, England : 1993) · 2025Article
- Effectiveness of Outer Hair Cells as Cochlear Amplifier: Coupled Oscillator Models.bioRxiv : the preprint server for biology · 2025Article
- Sound-evoked tonic motility of cochlear outer hair cells in mice with stereociliary defects.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Rate-dependent cochlear outer hair cell force generation: Models and parameter estimation.Biophysical journal · 2024Article
- Article
- Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Unloading outer hair cell bundles in vivo does not yield evidence of spontaneous oscillations in the mouse cochlea.Hearing research · 2022Article
- Coupling between outer hair cell electromotility and prestin sensor charge depends on voltage operating point.Hearing research · 2022Article
- Prestin-Mediated Frequency Selectivity Does not Cover Ultrahigh Frequencies in Mice.Neuroscience bulletin · 2022Article
- On the frequency response of prestin charge movement in membrane patches.Biophysical journal · 2022Article
- Cochlear outer hair cell electromotility enhances organ of Corti motion on a cycle-by-cycle basis at high frequencies in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- State dependent effects on the frequency response of prestin's real and imaginary components of nonlinear capacitance.Scientific reports · 2021Article
- The cochlear outer hair cell speed paradox.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Complex nonlinear capacitance in outer hair cell macro-patches: effects of membrane tension.Scientific reports · 2020Article
- Maturation of Voltage-induced Shifts in SLC26a5 (Prestin) Operating Point during Trafficking and Membrane Insertion.Neuroscience · 2020Article
- Cooperativity of KScience advances · 2020Article
- Diverse Mechanisms of Sound Frequency Discrimination in the Vertebrate Cochlea.Trends in neurosciences · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The outer hair cell (OHC) of the organ of Corti underlies a process that enhances hearing, termed cochlear amplification. The cell possesses a unique voltage-sensing protein, prestin, that changes conformation to cause cell length changes, a process termed electromotility (eM). The prestin voltage sensor generates a capacitance that is both voltage- and frequency-dependent, peaking at a characteristic membrane voltage (V
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.