Evidence map›Paper›PMID 31676317›Full record

ReviewExperimental neurology2020

MicroRNAs in central nervous system diseases: A prospective role in regulating blood-brain barrier integrity.

Feifei Ma, Xuejing Zhang, Ke-Jie Yin

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Feifei MaPittsburgh Institute of Brain Disorders & Recovery, Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Xuejing ZhangPittsburgh Institute of Brain Disorders & Recovery, Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Ke-Jie YinPittsburgh Institute of Brain Disorders & Recovery, Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA 15261, USA. Electronic address: yink2@upmc.edu.
University of Pittsburgh · US

Funding

MicroRNAs and post-stroke angiogenesisR01NS091175 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, JUN, YIN, KEJIE · 2015 to 2019
$2.5M
Kruppel-like factor 11 and ischemic strokeR01NS086820 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YIN, KEJIE · 2015 to 2019
$1.7M
Long non-coding RNAs and cerebrovascular endothelial cell pathology in ischemic strokeR21NS094930 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YIN, KEJIE · 2015 to 2016
$425k
NINDS NIH HHS R01 NS086820NINDS NIH HHS R01 NS091175NINDS NIH HHS R21 NS094930
6 · The paper itself

Abstract

Given the essential role of the blood-brain barrier (BBB) in the central nervous system (CNS), cumulative investigations have been performed to elucidate how modulation of BBB structural and functional integrity affects the pathogenesis of CNS diseases such as stroke, traumatic brain injuries, dementia, and cerebral infection. Recent studies have demonstrated that microRNAs (miRNAs) contribute to the maintenance of the BBB and thereby mediate CNS homeostasis. This review summarizes emerging studies that demonstrate cerebral miRNAs regulate BBB function in CNS disorders, emphasizing the direct role of miRNAs in BBB molecular composition. Evidence presented in this review will encourage a deeper understanding of the mechanisms by which miRNAs regulate BBB function, and facilitate the development of new miRNAs-based therapies in patients with CNS diseases.

Indexed as

Blood-Brain BarrierCentral Nervous System DiseasesMicroRNAsAnimalsHumansMicroRNAsBlood-brain barrierCentral nervous system diseasesMicroRNAsVascular integrity

Identifiers

PMID31676317
PMCPMC7304262
OpenAlexW2988774670

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.