Evidence map›Paper›PMID 31676231›Full record

ArticleMolecular cell2019

Recognition of Histone Crotonylation by Taf14 Links Metabolic State to Gene Expression.

Graeme J Gowans, Joseph B Bridgers, Jibo Zhang, Raghuvar Dronamraju, Anthony Burnetti, Devin A King, Aline V Thiengmany, Stephen A Shinsky, Natarajan V Bhanu, Benjamin A Garcia and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 120 citations in OpenAlex.

  1. Review
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  4. Linking cellular metabolism to chromatin modifications in plants.Journal of integrative plant biology · 2026
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Graeme J GowansDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Joseph B BridgersDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.
Jibo ZhangDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.
Raghuvar DronamrajuDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.
Anthony BurnettiDepartment of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC 27607, USA.
Devin A KingDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Aline V ThiengmanyDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Stephen A ShinskyDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
Natarajan V BhanuEpigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Benjamin A GarciaEpigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Nicolas E BuchlerDepartment of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC 27607, USA.
Brian D StrahlDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: brian_strahl@med.unc.edu.
Ashby J MorrisonDepartment of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address: ashbym@stanford.edu.
Stanford University · USUniversity of North Carolina at Chapel Hill · USNorth Carolina State University · USUniversity of Pennsylvania · USUNC Lineberger Comprehensive Cancer Center

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Mechanisms of chromatin and transcriptional regulationR35GM126900 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian D Strahl · 2018 to 2026
$5.5M
The Role of Chromatin in Metabolic Homeostasis SupplementalR35GM119580 · NIGMS · STANFORD UNIVERSITY · PI MORRISON, ASHBY J. · 2016 to 2025
$4.7M
Measuring and perturbing metabolic rhythms and the cell division cycle in single cellsR01GM127614 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI BUCHLER, NICOLAS EMILE · 2018 to 2021
$1.2M
NIEHS NIH HHS P30 ES013508NIGMS NIH HHS R01 GM127614NIGMS NIH HHS R35 GM119580NIGMS NIH HHS R35 GM126900
6 · The paper itself

Abstract

Metabolic signaling to chromatin often underlies how adaptive transcriptional responses are controlled. While intermediary metabolites serve as co-factors for histone-modifying enzymes during metabolic flux, how these modifications contribute to transcriptional responses is poorly understood. Here, we utilize the highly synchronized yeast metabolic cycle (YMC) and find that fatty acid β-oxidation genes are periodically expressed coincident with the β-oxidation byproduct histone crotonylation. Specifically, we found that H3K9 crotonylation peaks when H3K9 acetylation declines and energy resources become limited. During this metabolic state, pro-growth gene expression is dampened; however, mutation of the Taf14 YEATS domain, a H3K9 crotonylation reader, results in de-repression of these genes. Conversely, exogenous addition of crotonic acid results in increased histone crotonylation, constitutive repression of pro-growth genes, and disrupted YMC oscillations. Together, our findings expose an unexpected link between metabolic flux and transcription and demonstrate that histone crotonylation and Taf14 participate in the repression of energy-demanding gene expression.

Indexed as

Energy MetabolismGene Expression Regulation, FungalProtein Processing, Post-TranslationalAcyl Coenzyme AFatty AcidsHistonesHomeostasisLysineOxidation-ReductionSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSignal TransductionTranscription Factor TFIIDTranscription, GeneticAcyl Coenzyme Acrotonyl-coenzyme AFatty AcidsHistonesLysineSaccharomyces cerevisiae ProteinsTAF14 protein, S cerevisiaeTranscription Factor TFIID

Identifiers

PMID31676231
PMCPMC6931132
OpenAlexW2982630887

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.