ReviewTrends in biochemical sciences2020
Strategies for Development of a Next-Generation Protein Sequencing Platform.
Review in Trends in biochemical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Single-Molecule Conductance of Non-Redox Proteins: Mechanisms, Measurements, and Applications.Biomolecules · 2026Review
- Precise detection of single particles and bio-sensing applications on quartz crystal microbalance using non-linear resonance behavior.Microsystems & nanoengineering · 2026Article
- Review
- Principles ofbioRxiv : the preprint server for biology · 2026Article
- Bacterial Systematic Genetics and Integrated Multi-Omics: Beyond Static Genomics Toward Predictive Models.International journal of molecular sciences · 2025Review
- Nanopore ion sources deliver individual ions of amino acids and peptides directly into high vacuum.Nature communications · 2024Article
- A generalized protein identification method for novel and diverse sequencing technologies.NAR genomics and bioinformatics · 2024Article
- Promises and Challenges of populational Proteomics in Health and Disease.Molecular & cellular proteomics : MCP · 2024Article
- Whole protein sequencing and quantification without proteolysis, terminal residue cleavage, or purification: A computational model.bioRxiv : the preprint server for biology · 2024Article
- Peptide sequencing based on host-guest interaction-assisted nanopore sensing.Nature methods · 2024Article
- Origins, Technological Advancement, and Applications of Peptidomics.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Molecular sensitised probe for amino acid recognition within peptide sequences.Nature communications · 2023Article
- Beam search decoder for enhancing sequence decoding speed in single-molecule peptide sequencing data.PLoS computational biology · 2023Article
- Robust and scalable single-molecule protein sequencing with fluorosequencing.bioRxiv : the preprint server for biology · 2023Article
- Amino acid sequence assignment from single molecule peptide sequencing data using a two-stage classifier.PLoS computational biology · 2023Article
- Paleoproteomics.Chemical reviews · 2022Review
- Blocker Effect on Diffusion Resistance of a Membrane Channel: Dependence on the Blocker Geometry.The journal of physical chemistry. B · 2022Article
- Protein Sequencing, One Molecule at a Time.Annual review of biophysics · 2022Review
- Biological nanopores for single-molecule sensing.iScience · 2022Review
- Making the cut with protease engineering.Cell chemical biology · 2022Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Proteomic analysis can be a critical bottleneck in cellular characterization. The current paradigm relies primarily on mass spectrometry of peptides and affinity reagents (i.e., antibodies), both of which require a priori knowledge of the sample. An unbiased protein sequencing method, with a dynamic range that covers the full range of protein concentrations in proteomes, would revolutionize the field of proteomics, allowing a more facile characterization of novel gene products and subcellular complexes. To this end, several new platforms based on single-molecule protein-sequencing approaches have been proposed. This review summarizes four of these approaches, highlighting advantages, limitations, and challenges for each method towards advancing as a core technology for next-generation protein sequencing.
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Registered trials
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