ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2020
Compensatory Hippocampal Recruitment Supports Preserved Episodic Memory in Autism Spectrum Disorder.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neural dysfunctions associated with atypical memory in ASD: an ALE meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Brain correlates of declarative memory atypicalities in autism: a systematic review of functional neuroimaging findings.Molecular autism · 2023Pooled it
- Biochemical and Immunohistochemical Associations of TDP-43 and Cryptic RNA With Hippocampal and Amygdala Volumetrics in Alzheimer's Disease.Annals of neurology · 2026Article
- Overlapping and distinct intrinsic connectivity of hippocampal and triple networks in autistic individuals with and without a comorbid condition of ADHD.Frontiers in psychiatry · 2026Article
- The Role of the Brain's Pragmatic Language Network in Reading Comprehension in Autistic Children.Autism research : official journal of the International Society for Autism Research · 2025Article
- Single-nucleotide polymorphism analysis accurately predicts multiple impairments in hippocampal activity and memory performance in a murine model of idiopathic autism.Scientific reports · 2025Article
- Region-Specific Brain Volume Changes Emerge in Adolescence in the Valproic Acid Model of Autism and Parallel Human Findings.Developmental neuroscience · 2025Article
- Aerobic exercise improves cognitive flexibility and modulates regional volume changes in a rat model of autism.Behavioural brain research · 2024Article
- Age-related differences in the intrinsic connectivity of the hippocampus and ventral temporal lobe in autistic individuals.Frontiers in human neuroscience · 2024Article
- Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder.Frontiers in psychiatry · 2024Review
- Replicable Patterns of Memory Impairments in Children With Autism and Their Links to Hyperconnected Brain Circuits.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Atypical Associations between Functional Connectivity during Pragmatic and Semantic Language Processing and Cognitive Abilities in Children with Autism.Brain sciences · 2023Article
- Article
- Neural reinstatement of context memory in adults with autism spectrum disorder.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Atypical cognitive training-induced learning and brain plasticity and their relation to insistence on sameness in children with autism.bioRxiv : the preprint server for biology · 2023Article
- Relational memory weakness in autism despite the use of a controlled encoding task.Frontiers in psychology · 2023Article
- Neurobiological insights into twice-exceptionality: Circuits, cells, and molecules.Neurobiology of learning and memory · 2022Article
- Intact context memory performance in adults with autism spectrum disorder.Scientific reports · 2021Article
- The Effect of Comorbid Attention-Deficit/Hyperactivity Disorder Symptoms on Face Memory in Children with Autism Spectrum Disorder: Insights from Transdiagnostic Profiles.Brain sciences · 2021Article
- The Lost Neural Hierarchy of the Autistic Self-Locked-Out of the Mental Self and Its Default-Mode Network.Brain sciences · 2021Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe degree to which individuals with autism spectrum disorder (ASD) evidence impairments in episodic memory relative to their typically developing (TD) counterparts remains unclear. According to a prominent view, ASD is associated with deficits in encoding associations between items and recollecting precise context details. Here, we evaluated behavioral and neural evidence for this impaired relational binding hypothesis using a task involving relational encoding and recollection during functional magnetic resonance imaging.
methodsAdolescents and young adults (n
resultsThe ASD and TD groups showed indistinguishable item and associative recognition performance. During relational encoding, the ASD group demonstrated increased hippocampal recruitment, and decreased connectivity between MTL and PM regions relative to the TD group. Within ASD, hippocampal recruitment and MTL-PM connectivity were inversely correlated.
conclusionsThe lack of a behavioral deficit in ASD does not support the impaired relational binding hypothesis. Instead, the current data suggest that increased recruitment of the hippocampus compensates for decreased MTL-PM connectivity to support preserved episodic memory in ASD. These findings suggest a compensatory neurodevelopmental mechanism that may support preserved cognitive domains in ASD: local hyperrecruitment may offset connectivity aberrations in individuals with ASD relative to TD subjects.
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