SynthesisBMC health services research2019
The effectiveness of prescription drug monitoring programs at reducing opioid-related harms and consequences: a systematic review.
Synthesis in BMC health services research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Predictors of fatal and nonfatal overdose after prescription of opioids for chronic pain: a systematic review and meta-analysis of observational studies.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023Pooled it
- Evaluation of Interventions to Reduce Opioid Prescribing for Patients Discharged From the Emergency Department: A Systematic Review and Meta-analysis.JAMA network open · 2022Pooled it
- The ASAM/AAAP Clinical Practice Guideline on the Management of Stimulant Use Disorder.Journal of addiction medicineGuideline
- Understanding risk and protective factors associated with opioid misuse among at-risk adolescents and young adults in the emergency department.Drug and alcohol dependence · 2025Trial
- Outpatient opioid dispensing during the 2024 floods in Southern Brazil: a population-based ecological time-series analysis.Lancet regional health. Americas · 2026Article
- Establishment of a Novel Approach for Drug Abuse Monitoring and Its Application in Medical Institutions.Medical science monitor : international medical journal of experimental and clinical research · 2026Observational
- Impact of Prescription Drug Monitoring Programs on Postpartum Opioid Prescribing Practices.Health services research · 2026Article
- Impact of Prescription Drug Monitoring Program Implementation on Rates and Characteristics of People Seeing Multiple Prescribers in Primary Care: A Controlled Interrupted Time-Series Analysis.The Medical journal of Australia · 2026Article
- Impact of the COVID-19 pandemic on opioid toxicity mortality rates in Nova Scotia: An interrupted time series analysis (2009-2023).Canadian journal of public health = Revue canadienne de sante publique · 2026Article
- Purposeful Shared Decision-Making in Caring for and with Patients with Chronic Pain Receiving Opioid Therapy.Journal of general internal medicine · 2025Article
- Effects of state opioid prescribing laws on rates of fatal crashes in the USA.Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention · 2025Article
- Trend analysis and future projections of global burden of opioid use disorder (OUD) from 1990 to 2030.Frontiers in pharmacology · 2025Article
- Article
- Delivering MOUD to the Underserved: How Can Pharmacies Really Help?Journal of studies on alcohol and drugs · 2024Article
- Increased Use and Large Variation in Strong Opioids and Metamizole (Dipyrone) for Minor and Major Musculoskeletal Injuries Between 2008 and 2018: An Analysis of a Representative Sample of Swiss Workers.Journal of occupational rehabilitation · 2024Article
- Factors influencing pain medication and opioid use in patients with musculoskeletal injuries: a retrospective insurance claims database study.Scientific reports · 2024Article
- Prescription drug monitoring program use by opioid prescribers: a cross-sectional study.Health affairs scholar · 2023Article
- Accounting for the interplay of interpersonal and structural trauma in the treatment of chronic non-cancer pain, opioid use disorder, and mental health in urban safety-net primary care clinics.SSM. Mental health · 2023Article
- Accelerating Solutions for the Overdose Crisis: an Effectiveness-Implementation Hybrid Protocol for the HEAL Prevention Cooperative.Prevention science : the official journal of the Society for Prevention Research · 2023Article
- Leveraging the Full Continuum of Care to Prevent Opioid Use Disorder.Prevention science : the official journal of the Society for Prevention Research · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundIn order to address the opioid crisis in North America, many regions have adopted preventative strategies, such as prescription drug monitoring programs (PDMPs). PDMPs aim to increase patient safety by certifying that opioids are prescribed in appropriate quantities. We aimed to synthesize the literature on changes in opioid-related harms and consequences, an important measure of PDMP effectiveness.
methodsWe completed a systematic review. We conducted a narrative synthesis of opioid-related harms and consequences from PDMP implementation. Outcomes were grouped into categories by theme: opioid dependence, opioid-related care outcomes, opioid-related adverse events, and opioid-related legal and crime outcomes.
resultsWe included a total of 22 studies (49 PDMPs) in our review. Two studies reported on illicit and problematic use but found no significant associations with PDMP status. Eight studies examined the association between PDMP status and opioid-related care outcomes, of which two found that treatment admissions for prescriptions opioids were lower in states with PDMP programs (p < 0.05). Of the thirteen studies that reported on opioid-related adverse events, two found significant (p < 0.001 and p < 0.05) but conflicting results with one finding a decrease in opioid-related overdose deaths after PDMP implementation and the other an increase. Lastly, two studies found no statistically significant association between PDMP status and opioid-related legal and crime outcomes (crime rates, identification of potential dealers, and diversion).
conclusionOur study found limited evidence to support overall associations between PDMPs and reductions in opioid-related consequences. However, this should not detract from the value of PDMPs' larger role of improving opioid prescribing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.