ArticleRadiation oncology (London, England)2019
Adaptive radiotherapy for head and neck cancer reduces the requirement for rescans during treatment due to spinal cord dose.
Article in Radiation oncology (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Synthetic CT-enabled weekly adaptive radiotherapy for nasopharyngeal carcinoma: Optimizing plan adaptation triggers through volumetric-dosimetric monitoring.Journal of applied clinical medical physics · 2026Article
- Real-time morphological and dosimetric adaptation in nasopharyngeal carcinoma radiotherapy: insights from autosegmented fractional fan-beam CT.Radiation oncology (London, England) · 2025Article
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- A transformer-based hierarchical registration framework for multimodality deformable image registration.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2023Article
- Predicting the Tumour Response to Radiation by Modelling the Five Rs of Radiotherapy Using PET Images.Journal of imaging · 2023Article
- Ventilation and perfusion MRI at a 0.35 T MR-Linac: feasibility and reproducibility study.Radiation oncology (London, England) · 2023Article
- Article
- A retrospective analysis comparing set up errors from standard versus customised headrests for head and neck radiotherapy.Radiography (London, England : 1995) · 2022Article
- FMISO-Based Adaptive Radiotherapy in Head and Neck Cancer.Journal of personalized medicine · 2022Review
- Quantifying the dosimetric effects of neck contour changes and setup errors on the spinal cord in patients with nasopharyngeal carcinoma: establishing a rapid estimation method.Journal of radiation research · 2022Article
- Criteria for Verification and Replanning Based on the Adaptive Radiotherapy Protocol "Best for Adaptive Radiotherapy" in Head and Neck Cancer.Life (Basel, Switzerland) · 2022Article
- A novel TPS toolkit to assess correlation between transit fluence dosimetry and DVH metrics for adaptive head and neck radiotherapy.Physical and engineering sciences in medicine · 2021Article
- Alert system for monitoring changes in patient anatomy during radiation therapy of head and neck cancer.Journal of applied clinical medical physics · 2021Article
- Initial Feasibility and Clinical Implementation of Daily MR-Guided Adaptive Head and Neck Cancer Radiation Therapy on a 1.5T MR-Linac System: Prospective R-IDEAL 2a/2b Systematic Clinical Evaluation of Technical Innovation.International journal of radiation oncology, biology, physics · 2021Article
- Pelvic multi-organ segmentation on cone-beam CT for prostate adaptive radiotherapy.Medical physics · 2020Article
- Adaptive radiation therapy of breast cancer by repeated imaging during irradiation.World journal of radiology · 2020Review
- Accumulated Dose Deviation of Rotational and Residual Setup Errors on Nasopharyngeal Carcinoma Using MIM Treated by Helical Tomotherapy.Technology in cancer research & treatmentArticle
- Comparison of Three Commercial Methods of Cone-Beam Computed Tomography-Based Dosimetric Analysis of Head-and-Neck Patients with Weight Loss.Journal of medical physicsArticle
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5 authors.
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Abstract
backgroundPatients treated with radiotherapy for head and neck (H&N) cancer often experience anatomical changes. The potential compromises to Planning Target Volume (PTV) coverage or Organ at Risk (OAR) sparing has prompted the use of adaptive radiotherapy (ART) for these patients. However, implementation of ART is time and resource intensive. This study seeks to define a clinical trigger for H&N re-plans based on spinal cord safety using kV Cone-Beam Computed Tomography (CBCT) verification imaging, in order to best balance clinical benefit with additional workload.
methodsThirty-one H&N patients treated with Volumetric Modulated Arc Therapy (VMAT) who had a rescan CT (rCT) during treatment were included in this study. Contour volume changes between the planning CT (pCT) and rCT were determined. The original treatment plan was calculated on the pCT, CBCT prior to the rCT, pCT deformed to the anatomy of the CBCT (dCT), and rCT (considered the gold standard). The dose to 0.1 cc (D0.1cc) spinal cord was evaluated from the Dose Volume Histograms (DVHs).
resultsThe median dose increase to D0.1cc between the pCT and rCT was 0.7 Gy (inter-quartile range 0.2-1.9 Gy, p < 0.05). No correlation was found between contour volume changes and the spinal cord dose increase. Three patients exhibited an increase of 7.0-7.2 Gy to D0.1cc, resulting in a re-plan; these patients were correctly identified using calculations on the CBCT/dCT.
conclusionsAn adaptive re-plan can be triggered using spinal cord doses calculated on the CBCT/dCT. Implementing this trigger can reduce patient appointments and radiation dose by eliminating up to 90% of additional un-necessary CT scans, reducing the workload for radiographers, physicists, dosimetrists, and clinicians.
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