Evidence map›Paper›PMID 31675829›Full record

ArticleChaos (Woodbury, N.Y.)2019

Causality detection in cortical seizure dynamics using cross-dynamical delay differential analysis.

Claudia Lainscsek, Christopher E Gonzalez, Aaron L Sampson, Sydney S Cash, Terrence J Sejnowski

Abstract read
In one paragraph

Article in Chaos (Woodbury, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Decoding imagined speech with delay differential analysis.Frontiers in human neuroscience · 2024
    Article
  4. Article
  5. Article
  6. Dynamical differential covariance recovers directional network structure in multiscale neural systems.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Claudia LainscsekComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.ORCID 0000000210678961
Christopher E GonzalezComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
Aaron L SampsonComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.ORCID 0000000179731647
Sydney S CashDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.ORCID 0000000245576391
Terrence J SejnowskiComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.ORCID 0000000206227391

Funding

Multiscale modeling and large-scale recordings of trauma-induced epileptogenesisR01NS104368 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SEJNOWSKI, TERRENCE J · 2018 to 2022
$3.1M
DDALAB: Identifying Latent States from Neural Recordings with Nonlinear Causal AnalysisRF1MH132664 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SEJNOWSKI, TERRENCE J · 2023 to 2023
$1.2M
Nonlinear Causal Analysis of Neural SignalsR01EB026899 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SEJNOWSKI, TERRENCE J · 2018 to 2020
$1.0M
NIBIB NIH HHS R01 EB026899NIMH NIH HHS RF1 MH132664NINDS NIH HHS R01 NS104368
6 · The paper itself

Abstract

Most natural systems, including the brain, are highly nonlinear and complex, and determining information flow among the components that make up these dynamic systems is challenging. One such example is identifying abnormal causal interactions among different brain areas that give rise to epileptic activities. Here, we introduce cross-dynamical delay differential analysis, an extension of delay differential analysis, as a tool to establish causal relationships from time series signals. Our method can infer causality from short time series signals as well as in the presence of noise. Furthermore, we can determine the onset of generalized synchronization directly from time series data, without having to consult the underlying equations. We first validate our method on simulated datasets from coupled dynamical systems and apply the method to intracranial electroencephalography data obtained from epilepsy patients to better characterize large-scale information flow during epilepsy.

Indexed as

ElectroencephalographyModels, NeurologicalSignal Processing, Computer-AssistedBrainHumansNonlinear DynamicsSeizures

Identifiers

PMID31675829
PMCPMC6783296

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.