ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019
Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The trial behind it
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Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- Desflurane and sevoflurane concentrations in blood passing through the oxygenator during cardiopulmonary bypass: a randomized prospective pilot study.Journal of anesthesia · 2020Trial
- Sevoflurane blood concentrations in patients undergoing mild and moderate hypothermic cardiac surgery: a prospective observational study.BMC anesthesiology · 2026Observational
- The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Deciphering sevoflurane-induced neurotoxicity: from isolated targets to intricate regulatory networks.Frontiers in neuroscience · 2025Review
- Dexmedetomidine directly binds to and inhibits Toll-like receptor 4.International immunopharmacology · 2024Article
- Mechanism of isoflurane‑mediated breast cancer growthOncology letters · 2024Article
- The landscape of immune dysregulation in pediatric sepsis at a single-cell resolution.Clinical immunology (Orlando, Fla.) · 2024Article
- Cystic Fibrosis Mice Are Highly Susceptible to Repeated AcuteBioMed research international · 2024Article
- Toll-like receptors and integrins crosstalk.Frontiers in immunology · 2024Review
- The relationship between anesthesia, surgery and postoperative immune function in cancer patients: a review.Frontiers in immunology · 2024Review
- Volatile sedation in sepsis: a promising therapeutic approach or a venture doomed to fail?BJA open · 2022Article
- Propofol directly binds to and inhibits TLR7.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Isoflurane attenuates sepsis-associated lung injury.Biochemical and biophysical research communications · 2022Article
- Sevoflurane Dampens Acute Pulmonary Inflammation via the Adenosine Receptor A2B and Heme Oxygenase-1.Cells · 2022Article
- Isoflurane Attenuates Cerebral Ischaemia-Reperfusion Injury via the TLR4-NLRP3 Signalling Pathway in Diabetic Mice.Oxidative medicine and cellular longevity · 2022Article
- αDβ2 as a novel target of experimental polymicrobial sepsis.Frontiers in immunology · 2022Article
- The immunomodulatory mechanism of dexmedetomidine.International immunopharmacology · 2021Review
- Anesthetics isoflurane and sevoflurane attenuate flagellin-mediated inflammation in the lung.Biochemical and biophysical research communications · 2021Article
- The Role of Anesthetic Management in Surgical Site Infections After Pediatric Intestinal Surgery.The Journal of surgical research · 2021Article
- Mechanistic consideration of the effect of perioperative volatile anesthetics on phagocytes.Clinical immunology (Orlando, Fla.) · 2021Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
General anesthesia has been the requisite component of surgical procedures for over 150 yr. Although immunomodulatory effects of volatile anesthetics have been growingly appreciated, the molecular mechanism has not been understood. In septic mice, the commonly used volatile anesthetic isoflurane attenuated the production of 5-lipoxygenase products and IL-10 and reduced CD11b and intercellular adhesion molecule-1 expression on neutrophils, suggesting the attenuation of TLR4 signaling. We confirmed the attenuation of TLR4 signaling
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.