SynthesisInternational journal of dental hygiene2020
What is the effect of active ingredients in dentifrice on inhibiting the regrowth of overnight plaque? A systematic review.
Synthesis in International journal of dental hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- What is the effect of active ingredients in dentifrice on inhibiting the regrowth of overnight plaque? A systematic review.International journal of dental hygiene · 2020Pooled it
- Effectiveness of a novel amine + zinc + fluoride toothpaste in reducing plaque and gingivitis: results of a six-month randomized controlled trial.BMC oral health · 2025Trial
- Impact of Different Regimens of Fluoridated Dentifrice Application on the pH and Inorganic Composition in an Oral Microcosm Biofilm Model.Microorganisms · 2025Article
- Article
- The effect of whitening toothpastes on the surface properties and color stability of different ceramic materials.BMC oral health · 2024Article
- In-Vitro Tooth Cleaning Efficacy and Filament End Rounding of Different Manual Children's Toothbrushes.Oral health & preventive dentistry · 2024Article
- Effect of Dentifrice Ingredients on Volume and Vitality of a Simulated Periodontal Multispecies Biofilm.Dentistry journal · 2024Article
- Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel.Biomimetics (Basel, Switzerland) · 2023Article
- Revisiting Oral Antiseptics, Microorganism Targets and Effectiveness.Journal of personalized medicine · 2023Review
- Antimicrobial Effect of Low-Fluoride Toothpastes Containing Polyphosphate and Polyols: An In Vitro Assessment of Inhibition Zones.Antibiotics (Basel, Switzerland) · 2023Article
- Bioactive Materials for Caries Management: A Literature Review.Dentistry journal · 2023Review
- A Combination of Zinc and Arginine Disrupt the Mechanical Integrity of Dental Biofilms.Microbiology spectrum · 2023Article
- Digital imaging and qPCR analysis and comparison of short-term plaque removal effects of toothbrushing.Frontiers in dental medicine · 2023Article
- Chemical vs. natural toothpaste: which formulas for which properties? A scoping review.Journal of public health in Africa · 2022Article
- Diamond particles in toothpastes: in-vitro effect on the abrasive enamel wear.BMC oral health · 2022Article
- Microbial approaches for the assessment of toothpaste efficacy against oral species: A method comparison.MicrobiologyOpen · 2022Article
- Effect of the toothbrush tuft arrangement and bristle stiffness on the abrasive dentin wear.Scientific reports · 2022Article
- Recent Development of Active Ingredients in Mouthwashes and Toothpastes for Periodontal Diseases.Molecules (Basel, Switzerland) · 2021Review
- Dentin Abrasivity and Cleaning Efficacy of Novel/Alternative Toothpastes.Oral health & preventive dentistry · 2020Article
- Triclosan inhibits the activation of human periodontal ligament fibroblasts induced by lipopolysaccharide fromJournal of biomedical research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this systematic review was to establish the adjuvant clinical effect of brushing with a dentifrice containing purported active ingredients as compared to a regular sodium fluoride dentifrice with respect to the inhibition of overnight dental plaque regrowth from studies with human participants.
methodsMEDLINE-PubMed, EMBASE and Cochrane CENTRAL were searched, up to June 2019. The inclusion criteria were controlled clinical trials with participants aged ≥ 18 years in good general health. Studies were included that evaluated the effect of toothbrushing with a dentifrice on the inhibition of overnight dental plaque regrowth when an active ingredient was added to the dentifrice as compared to a common sodium fluoride product. Data were extracted from the eligible studies, the risk of bias was assessed, and a meta-analysis was performed where feasible.
resultIndependent screening of 213 unique papers resulted in 10 eligible publications that provided 14 comparisons. Stannous fluoride and triclosan dentifrices were found as the active ingredients. The descriptive analysis indicated that all, but two comparisons demonstrated an additional effect on the active-ingredient dentifrice. The meta-analysis supported and strengthened these findings. It showed that when plaque was scored digitally, a DiffM was -3.15(95% CI [-4.61:-1.69], P < .001, prediction interval [-5.07;-1.24]). When plaque was scored clinically, the difference of means (DiffM) was -0.33(95% CI [-0.49:-0.16], P < .001, prediction interval [-0.87; 0.21]).
conclusionThe results of this review demonstrate moderate-quality evidence that brushing with an active-ingredient dentifrice with stannous fluoride or triclosan does provide an added clinically relevant effect concerning plaque inhibition capabilities that surpass the effect of a regular sodium fluoride dentifrice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.